Dr Laura Sadofsky

Dr Laura Sadofsky is a non-clinical lecturer in Respiratory Medicine in the Centre for Cardiovascular and Metabolic Research.

MORGAN, K., SADOFSKY, L. R., CROW, C. & MORICE, A. H. 2014. Human TRPM8 and TRPA1 pain channels, including a gene variant with increased sensitivity to agonists (TRPA1 R797T), exhibit differential regulation by SRC-tyrosine kinase inhibitor. Biosci Rep, 34.


SADOFSKY, L. R., SREEKRISHNA, K. T., LIN, Y., SCHINAMAN, R., GORKA, K., MANTRI, Y., HAUGHT, J. C., HUGGINS, T. G., ISFORT, R. J., BASCOM, C. C. & MORICE, A. H. 2014. Unique Responses are Observed in Transient Receptor Potential Ankyrin 1 and Vanilloid 1 (TRPA1 and TRPV1) Co-Expressing Cells. Cells, 3, 616-26.


SADOFSKY, L. R., RAMACHANDRAN, R., CROW, C., COWEN, M., COMPTON, S. J. & MORICE, A. H. 2012. Inflammatory stimuli up-regulate transient receptor potential vanilloid-1 expression in human bronchial fibroblasts. Exp Lung Res, 38, 75-81.


NASSINI, R., MATERAZZI, S., VRIENS, J., PRENEN, J., BENEMEI, S., DE SIENA, G., LA MARCA, G., ANDRE, E., PRETI, D., AVONTO, C., SADOFSKY, L., DI MARZO, V., DE PETROCELLIS, L., DUSSOR, G., PORRECA, F., TAGLIALATELA-SCAFATI, O., APPENDINO, G., NILIUS, B. & GEPPETTI, P. 2012. The 'headache tree' via umbellulone and TRPA1 activates the trigeminovascular system. Brain, 135, 376-90.


BOTHAM, A., GUO, X., XIAO, Y. P., MORICE, A. H., COMPTON, S. J. & SADOFSKY, L. R. 2011. Palmitoylation of human proteinase-activated receptor-2 differentially regulates receptor-triggered ERK1/2 activation, calcium signalling and endocytosis. Biochem J, 438, 359-67.


XIAO, Y. P., MORICE, A. H., COMPTON, S. J. & SADOFSKY, L. 2011. N-linked glycosylation regulates human proteinase-activated receptor-1 cell surface expression and disarming via neutrophil proteinases and thermolysin. J Biol Chem, 286, 22991-3002.


SADOFSKY, L. R., BOA, A. N., MAHER, S. A., BIRRELL, M. A., BELVISI, M. G. & MORICE, A. H. 2011. TRPA1 is activated by direct addition of cysteine residues to the N-hydroxysuccinyl esters of acrylic and cinnamic acids. Pharmacol Res, 63, 30-6.


NASSINI, R., MATERAZZI, S., ANDRE, E., SARTIANI, L., ALDINI, G., TREVISANI, M., CARNINI, C., MASSI, D., PEDRETTI, P., CARINI, M., CERBAI, E., PRETI, D., VILLETTI, G., CIVELLI, M., TREVISAN, G., AZZARI, C., STOKESBERRY, S., SADOFSKY, L., MCGARVEY, L., PATACCHINI, R. & GEPPETTI, P. 2010. Acetaminophen, via its reactive metabolite N-acetyl-p-benzo-quinoneimine and transient receptor potential ankyrin-1 stimulation, causes neurogenic inflammation in the airways and other tissues in rodents. FASEB J, 24, 4904-16.


BIRRELL, M. A., BELVISI, M. G., GRACE, M., SADOFSKY, L., FARUQI, S., HELE, D. J., MAHER, S. A., FREUND-MICHEL, V. & MORICE, A. H. 2009. TRPA1 agonists evoke coughing in guinea pig and human volunteers. Am J Respir Crit Care Med, 180, 1042-7.


SADOFSKY, L. R., CAMPI, B., TREVISANI, M., COMPTON, S. J. & MORICE, A. H. 2008. Transient receptor potential vanilloid-1-mediated calcium responses are inhibited by the alkylamine antihistamines dexbrompheniramine and chlorpheniramine. Exp Lung Res, 34, 681-93.


RAMACHANDRAN, R., SADOFSKY, L. R., XIAO, Y., BOTHAM, A., COWEN, M., MORICE, A. H. & COMPTON, S. J. 2007. Inflammatory mediators modulate thrombin and cathepsin-G signaling in human bronchial fibroblasts by inducing expression of proteinase-activated receptor-4. Am J Physiol Lung Cell Mol Physiol, 292, L788-98.


MITCHELL, J. E., CAMPBELL, A. P., NEW, N. E., SADOFSKY, L. R., KASTELIK, J. A., MULRENNAN, S. A., COMPTON, S. J. & MORICE, A. H. 2005. Expression and characterization of the intracellular vanilloid receptor (TRPV1) in bronchi from patients with chronic cough. Exp Lung Res, 31, 295-306.


 

Delivers plenaries for phase I students


Runs and organises pharmacology workshops and resource sessions for phase I students


Contributes to the CCMR SSIP including running a laboratory practical


Supervises research students including undergraduates and postgraduates


Academic Lead for Postgraduate Training.  This involves being part of the Post Graduate Examination Board and the Postgraduate Research Board.


Module coordinator for three HYMS Postgraduate Training Scheme modules (Communicating Effectively Verbal, Communicating Effectively Written and Facilitating Learning)

British Association for Lung Research committee member


Member of the British Pharmacological Society and European Respiratory Society


Contact details

01482 461876; 01482 465008

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