Paul's work focuses on antigen presenting cells, with a particular emphasis on the temporal and tissue-specific changes that occur in the APC compartment during the progression of inflammatory and infectious disease. Although experimental models of visceral leishmaniasis provide the major context in which these studies are performed, the laboratory has more recently introduced other infectious and non-infectious models to complement and extend these studies. Ongoing projects span fundamental research into macrophage and dendritic cell development, heterogeneity and function, and translational projects aimed at taking this knowledge forward for the development of new therapeutic tools and vaccines.