Khalid's research aims to identify novel biochemical and molecular mechanisms that contribute to platelet activity implicated in defective haemostasis. His team's major interests include the role of cyclic nucleotides in modulating platelet function, the link between adipocytokines and thrombosis, the molecular basis of platelet-based bleeding disorders, and glucocorticoid receptor function in platelets.
The main aim of Thomas's research is to improve the treatment of patients who suffer from cardiovascular conditions, by improving our understanding of the roles played by signalling systems in cardiovascular disease, and by identifying pharmacological targets for new drugs. His research is particularly significant in combining basic and translational research to improve the prediction and treatment of cardiovascular diseases.
Aiming to find new therapeutic strategies, he follows the strategy of molecular investigation, followed by evaluation in experimental models, and finally establishing proof-of-concept in humans.