collaborations

collaborations

Modified ITT

Clinical trials in palliative care are hard to conduct, and patient data is particularly precious - provided by patients who are unwell. It is important we find the best methods to analyse clinical trial participants under these circumstances.

About the project

Funder: University of Hull
Time frame: 2018
Contact for more details:  Professor David Currow ( david.currow@hyms.ac.uk) and  Professor Miriam Johnson ( miriam.johnson@hyms.ac.uk)

The purpose of this project is to explore the effect of a modified intention-to-treat (ITT) analysis on the power and effect size of clinical trials in palliative care.

In conventional ITT, patients who withdraw after randomisation but before they receive study intervention are included in the trial analysis. This study explores the effect on study power and effect size if these participants are excluded, using completed palliative care trials as worked examples.