My group has worked to identify antigens that can act as targets for immunotherapy (where the immune system is stimulated to kill diseased cells) but we also identify biomarkers for the early detection of disease.
Currently we are looking for antigens that can be used as targets for the therapy of acute leukaemia, ovarian cancer, and endometriosis. We have shown that antigens can act as biomarkers for disease (diagnosis, survival and subtype) as well as providing new insights into the biology underlying these difficult to treat diseases.
Barbara studied genetics at the University of Wales, Aberyswyth and leukaemia at the University of Wales College of Medicine Cardiff. Her postdoctoral work took her to the University of Toronto, and she started her first research group at King's College London.
Research in the Guinn Lab focusses on non-invasive biomarkers for the early detection of endometriosis and ovarian cancer. In addition members of the group are identifying tumour antigens that can act as new targets for therapy.
Dr Guinn welcomes applications from students who want to study postgraduate research degrees (MSc by Research, MD and PhD) in the Centre for Biomedicine, Hull York Medical School.
My group is particularly interested in difficult to diagnose and/or treat diseases. Currently this includes acute leukaemias, ovarian and lung cancer, and endometriosis, and has led to the identification of biomarkers for survival, target for therapies and improved our understanding of the biological basis of disease.
For more information about possible PhD projects please contact hybg5@hyms.ac.uk
Associate Editor, Journal of Translational Medicine
Member of European Association for Cancer Research (EACR)
Guest Editor of the Special Issue on 'Molecular Mechanisms underlying, and Therapies targeting, Acute Myeloid Leukaemia' in International Journal of Molecular Sciences
Review Editor for Frontiers in Oncology
External Examiner for BSc Biomedical Science at Queen's University Belfast.
External Examiner for MSc Medical Molecular Biology with Genetics and MRes in Molecular Medicine at the University of Bangor.