Dr Rivero is a molecular cell biologist who specialises in research into functional and regulatory aspects of the cytoskeleton, the signalling pathways that regulate its remodelling and its relevance in disease processes.
MBBS from the University of Valladolid (1989). PhD at the Institute of Biochemistry, CSIC-Universidad Complutense, Madrid (1994). Postdoctoral research fellow in Germany at the Max-Planck Institute for Biochemistry, Martinsried (1994-1997) and at the University of Cologne (1997-1998). Scientific Assistant and Group Leader at the Center for Biochemistry, Medical Faculty, University of Cologne (1998-2007). In 2007 he joined Hull York Medical School as a Senior Lecturer and was promoted to Reader in 2017.
Dr Rivero's lab specialises in research into the cytoskeleton, a key player in almost all cellular processes, including motility, cytokinesis, cell-to-cell and cell-susbstrate interactions and intracellular transport. Dr. Rivero is currently pursuing lines of research that explore aspects of the actin cytoskeleton and the signalling pathways that regulate its remodelling in vells of the cardiovascular system, most notably platelets. Platelet physiology is of particular medical relevance because of the role of thrombosis in common cardiovascular conditions such as heart attack and stroke.
The ultimate goals of this research are a better understanding of platelet function (basic science aspect) and the development of improved diagnostic/therapeutical strategies for the management of states of platelet hyperactivation and other conditions involving platelet/endothelial cell function (translational aspect).The interest in cell signalling extends to the effects of climate change on cell function. Dr. Rivero's lab uses the eukaryote model organism Dictyostelium discoideum to investigate the effects of heat waves at the proteome and transcriptome levels, with an emphasis on multicellular development and metabolism.
Dr. Rivero contributes to various aspects of the Hull York Medical School MBBS programme (lectures, biopracticals, scholarship and special interest programme), to the BSc in Biomedical Sciences and to the MSc in Pharmacology and Drug Development, the MSc in Biomedical Sciences and the MSc Frontiers in Planetary Science.
Dr. Rivero is the Graduate Research Director at the Centre for Biomedicine.
View Dr. Rivero's publications on Worktribe.
Selected publications
D.R.J. Riley, J. Khalil. J. Pieters, K. M. Naseem, F. Rivero. Coronin 1 is required for integrin beta2 translocation in platelets. International Journal of Molecular Sciences, 21:356 (2020).
D.R.J. Riley, J. Khalil. K. M. Naseem, F. Rivero. Biochemical and immunocytochemical characterization of coronins in platelets. Platelets, in press.
M. Berger, D.R.J. Riley, J. Lutz, J. Khalil, A. Aburima, K. Naseem, F. Rivero. Alterations in platelet alpha-granule secretion and adhesion on collagen under flow in mice lacking the atypical Rho GTPase RhoBTB3. Cells. 8:149 (2019).
P. Joshi, D. R. J. Riley, J. S. Khalil, H. Xiong, W. Ji, F. Rivero. The membrane-associated fraction of cyclase translocates to the cytosol upon platelet stimulation. Scientific Reports, 8:10804 (2018).
F. Krey, R.A. Dumont, E.S Krystofiak, S. Vijayakumar, D. Choi, F. Rivero, B. Kachar, S.M. Jones, P.G. Barr-Gillespie. Plastin-1 widens stereocilia by transforming actin filament packing from hexagonal to liquid. Journal of Cell Biology, 215:467-482 (2016).
R. Taylor, A Bullen, S.L. Johnson, E-M. Grimm-Günter, F. Rivero, W. Marcotti, A. Forge, N. Daudet. Absence of plastin 1 causes abnormal maintenance of hair cell stereocilia and a progressive form of hearing loss in mice. Human Molecular Genetics, 24:37-49 (2015).
J. Lutz, E-M. S. Grimm-Gunter, P. Jooshi, F. Rivero. Expression analysis of mouse Rhobtb3 using a LacZ reporter and preliminary characterization of a knockout strain. Histochemistry and Cell Biology, 142:511-528 (2014).
K. Swaminathan, A. Muller-Taubenberger, J. Faix, F. Rivero, A.A. Noegel. A CRIB domain mediates functions of coronin. Proceedings of the National Academy of Sciences USA, 111:E25-33 (2014).
Prof. Khalid Naseem (School of Medicine, University of Leeds)Prof. George Baillie (School of Cardiovascular and Metabolic Health, University of Glasgow)
Dr. Mohammed M. Idris (CSIR-Centre for Cellular and Molecular Biology, Hyderabad)
Dr. Katharina C. Wollenberg-Valero (School of Biology and Environmental Science, University College Dublin)
Prof. Christian Hamman (Health and Medical University Potsdam)
Dr Rivero welcomes applications from students who want to study postgraduate research degrees (MSc by Research and PhD) in the Centre for Biomedicine. For more information please contact by e-mail.
My group is interested in understanding the molecular basis of disease by addressing cell signalling in the cardiovascular system and the effects of climate change on cell function.
Dr. Rivero is member of the editorial board of BMC Molecular and Cell Biology and Section Editor-in-Chief of Cells.
Dr. Rivro is member and ambassador of the British Society for Cell Biology (BSCB) fand member of the Biochemical Society and the Platelet Society.