Professor Ian Chetter

Professor Ian Chetter was appointed as the Professor of Surgery at Hull York Medical School /University of Hull and Honorary Consultant Vascular Surgeon at Hull University Teaching Hospitals NHS Trust in February 2011. He qualified from University of Leeds Medical School in 1990, and completed his basic and higher surgical training in Yorkshire. Funded by a Northern and Yorkshire Research Fellowship he obtained MD from the University of Leeds and was awarded a Hunterian Professorship from the Royal College of Surgeons of England in 2000. Following a 12 month Vascular Fellowship in Adelaide, Australia funded by an Ethicon/ Peter Clifford Fellowship in 2002/3, Ian returned to the UK to be appointed Senior Lecturer at the Academic Vascular Surgical Unit in Hull. Professor Chetter received a five year NIHR Senior Investigators Award in April 2018.

Professor Chetter is the Royal College of Surgeons Surgical Specialty Lead for Research in Vascular Surgery and is also currently Chair of the Research Committee, an Executive Committee Member, and Committee Member for the Vascular Society of Great Britain and Ireland.

• MBChB – 1990 (University of Leeds)
• FRCS (Eng) – 1994
• MD – 2000 (University of Leeds)
• FRCS (Gen Surg) – 2002
• Postgraduate Certificate in Medical Ultrasound – 2005 (University of Leeds)
• Postgraduate Diploma in Clinical Education – 2011 (University of Newcastle)

Professor Chetter’s interests are predominantly Health Services Research and New and Emerging Technologies in arterial and venous disease, wound healing and surgical site infection. In addition he has interests in the molecular biology of aneurysmal disease, ischaemia reperfusion, translational research in therapies for intermittent claudication and educational research analysing the value of endovascular simulation.

Current projects

• Endovenous therapies for lower limb superficial venous incompetence/long term follow-up of patients
• Evaluating the benefits and mechanism of supervised exercise in claudicants
• HIIT proof of concept in patients with intermittent claudication
• Surgical wounds healing by secondary intention
  • National Multicentre RCT to assess the clinical and cost effectiveness of negative pressure wound therapy versus usual care for surgical wounds healing by secondary intention (SWHSI-2)
  • validation of participants’ own wound healing photographs
  • mechanisms of action in predicting wound healing
• ACE inhibitors in claudicants
• Shockwave therapy for diabetic foot wounds
• Clinical and histopathological factors affecting patency of arteriovenous fistulae
• Cardiovascular physiology in patients undergoing aortic aneurysm repair – long term follow-up
• Validation of WoundQoL
• Surgical site infection in clean surgery
• Vascular Priority Setting Partnership project to develop a national top ten list of research questions and the formation of Specialist Interest Groups to support research in the areas of
• Development of a claudication risk checker

Grants

Most recent:

• VENUS 6: A Randomised Controlled Trial of compression therapies for the treatment of venous leg ulcers (Co-applicant - NIHR HTA Grant 2020 – 2024)
• INITIATE: High INtensity Interval Training In pATiEnts with intermittent claudication: a proof-of-concept trial (PI – NIHR RfPB Grant 2019 – 2021)
• SWHSI 2: Effectiveness and cost effectiveness of Negative Wound Therapy versus usual care for surgical wounds healing by secondary intention (PI – NIHR HTA Grant 2018 – 2022)
• Multiple Interventions for Diabetic Food Ulcer Treatment (MIDFUT) Trial (Collaborator – NIHR Programme Grant 2017-2022)
• NIHR Senior Investigators Award (2018 – 2022)
• RCS Vascular Surgical Specialty Lead (2016 – 2019)
• SWHSI 1Surgical wounds healing by secondary intention: characterising and quantifying the problem and identifying effective treatments (PI NIHR Programme Grant 2011 – 2016)
• NESIC: A Multicentre Randomised Controlled Study: Does Neuromuscular Electrical Stimulation Improve the Absolute Walking Distance in Patients with Intermittent Claudication compared to best available treatment? (Co-Investigator MHRA EME Grant 2018 – 2020)
• Basil 2: Multi-centre randomised controlled trial to compare the clinical and cost-effectiveness of a "vein bypass first" with a "best endovascular first" revascularisation strategy for severe limb ischaemia due to infra-geniculate arterial disease (Co-applicant NIHR HTA Grant 2014 – 2023)
• Basil 3: Multi-centre randomised controlled trial of clinical and cost-effectiveness of drug coated balloons, drug eluting stents and plain balloon angioplasty with bail-out bare metal stent revascularisation strategies for severe limb ischaemia due to femoropopliteal disease (Co-applicant NIHR HTA Grant 2017 – 2021)

Course development

Vascular Society of Great Britain and Ireland:

• Development of ASPIRE Educational Programme of Courses for Vascular Trainees ST3 – ST8.
• Academic conference is in the planning stages with plans to run the conference in Hull in 2021

Postgraduate Teaching

• Supervisor for Leeds PG Cert Ultrasound Course

Undergraduate

• Major contribution to development of undergraduate RCS courses (Anatomy Summer School and Surgical Skills for Students)
• Phase 1 clinical placement tutor and Phase 3 tutor
• Contributed to development and provision of HAiRT course
• iBSc supervisor
• Developed and provided SSCs

Developing teaching skills in others

• Supervise and support research fellow undertaking MClinEd
• All research fellows undergo formal Hull York Medical School training in teaching and assessment

Examiner

• 1st, 2nd, 4th and 5th year Hull York Medical School students
• Internal examiner for the University of Hull
• External examiner for Universities of Newcastle and Leeds

2012

F A K Mazari, J A Khan, D Carradice, N Samuel, M N A Abdulrahman, S Gulati, H L D Lee, T A Mehta, P T McCollum, I C Chetter

Randomized clinical trial of percutaneous transluminal angioplasty, supervised exercise and combined treatment for intermittent claudication due to femoropopliteal arterial disease

British Journal of Surgery January 2012 99(1) 39-48   Doi:10.1002/bjs.7710

L A Green, I C Chetter

Procedure based assessments: an evaluation of their role in reflective learning

Annals of Royal College of Surgeons of England January 2012 94: (Suppl) 28-31

Doi:10.13008/147363512X131895264437838

Y Shahin, J A Khan, I Chetter

Angiotensin converting enzyme inhibitors effect arterial stiffness and wave reflections: A meta –analysis and meta-regression of randomised controlled trials

Atherosclerosis March 12 221 (1): 18-33   Doi:10.1016/j.atherosclerosis.2011.12.005

G E Smith, R Gohil, I Chetter

Factors affecting the patency of arteriovenous fistulae for dialysis access

Journal of Vascular Surgery March 12 55 (3): 849-855   Doi:10.1016/j.jvs.2011.07.095

N Samuel, D Carradice, A I Mekako, T Wallace, J Hatfield, I C Chetter

Randomised trial of endovenous laser ablation versus surgery for small saphenous varicose veins

British Journal of Surgery March 12 99 (S3): 13   Doi:10.1002/bjs.8725

2011

Comparing the treatment response of great saphenous and small saphenous vein incompetence following surgery and endovenous laser ablation: a retrospective cohort study. Carradice D, Samuel N, Wallace T, Mazari FA, Hatfield J, Chetter I. Phlebology. 2011 Aug 3. [Epub ahead of print]

Patients' Perspective of Functional Outcome After Elective Abdominal Aortic Aneurysm Repair: A Questionnaire Survey.Khan JA, Mazari FA, Abdul Rahman MN, Mockford K, Chetter IC, McCollum PT. Ann Vasc Surg. 2011 Jul 27. [Epub ahead of print]

Great saphenous vein transposition to the forearm for dialysis vascular access; an under used autologous option? Smith GE, Carradice D, Samuel N, Gohil R, Chetter IC. J Vasc Access. 2011 Jun 1. [Epub ahead of print]

Targeted Duplex Ultrasound in a One-Stop Dialysis Vascular Access Assessment Clinic. Smith GE, Samuel N, Khan J, Johnson BF, Chetter IC. Ann Vasc Surg. 2011 Jun 11. [Epub ahead of print]

Clinical and technical outcomes from a randomized clinical trial of endovenous laser ablation compared with conventional surgery for great saphenous varicose veins. Carradice D, Mekako AI, Mazari FA, Samuel N, Hatfield J, Chetter IC. Br J Surg. 2011 Aug;98(8):1117-23.

Modelling the effect of venous disease on quality of life. Carradice D, Mazari FA, Samuel N, Allgar V, Hatfield J, Chetter IC. Br J Surg. 2011 Aug;98(8):1089-98.

Angiotensin converting enzyme inhibitors effect on endothelial dysfunction: a meta-analysis of randomised controlled trials.Shahin Y, Khan JA, Samuel N, Chetter I. Atherosclerosis. 2011 May;216(1):7-16.

Randomized clinical trial of endovenous laser ablation compared with conventional surgery for great saphenous varicose veins. Carradice D, Mekako AI, Mazari FA, Samuel N, Hatfield J, Chetter IC. Br J Surg. 2011 Apr;98(4):501-10.

Do angiotensin converting enzyme inhibitors improve walking distance in patients with symptomatic lower limb arterial disease? A systematic review and meta-analysis of randomised controlled trials. Shahin Y, Mazari F, Chetter I. Int J Surg. 2011;9(3):209-13.

A randomized placebo controlled trial of the effect of preoperative statin use on matrix metalloproteinases and tissue inhibitors of matrix metalloproteinases in areas of low and peak wall stress in patients undergoing elective open repair of abdominal aortic aneurysm. Rahman MN, Khan JA, Mazari FA, Mockford K, McCollum PT, Chetter IC. Ann Vasc Surg. 2011 Jan;25(1):32-8.

Computerized dynamic posturography in the objective assessment of balance in patients with intermittent claudication.Mockford KA, Mazari FA, Jordan AR, Vanicek N, Chetter IC, Coughlin PA. Ann Vasc Surg. 2011 Feb;25(2):182-90.

2010

Hull early walking aid for rehabilitation of transtibial amputees--randomized controlled trial (HEART). Mazari FA, Mockford K, Barnett C, Khan JA, Brown B, Smith L, Polman RC, Hancock A, Vanicek NK, Chetter IC. J Vasc Surg. 2010 Dec;52(6):1564-71.

Randomized clinical trial of tranexamic acid-free fibrin sealant during vascular surgical procedures. Chalmers RT, Darling Iii RC, Wingard JT, Chetter I, Cutler B, Kern JA, Hart JC. Br J Surg. 2010 Dec;97(12):1784-9.

Obstacles in initiating a new research project--reflection on medical research in UK. Khan JA, Mazari FA, Chetter IC, McCollum PT. Int J Surg. 2010;8(8):656-7.

Kinematic adaptations to ischemic pain in claudicants during continuous walking.Mockford KA, Vanicek N, Jordan A, Chetter IC, Coughlin PA. Gait Posture. 2010 Jul;32(3):395-9.

Energy delivery during 810 nm endovenous laser ablation of varicose veins and post-procedural morbidity. Carradice D, Mazari FA, Mekako A, Hatfield J, Allgar V, Chetter IC. Eur J Vasc Endovasc Surg. 2010 Sep;40(3):393-8.

An analysis of relationship between quality of life indices and clinical improvement following intervention in patients with intermittent claudication due to femoropopliteal disease. Mazari FA, Carradice D, Rahman MN, Khan JA, Mockford K, Mehta T, McCollum PT, Chetter IC. J Vasc Surg. 2010 Jul;52(1):77-84.

Randomized clinical trial of co-amoxiclav versus no antibiotic prophylaxis in varicose vein surgery. Mekako AI, Chetter IC, Coughlin PA, Hatfield J, McCollum PT; Hull Antibiotic pRophylaxis in varicose Vein Surgery Trialists (HARVEST). Br J Surg. 2010 Jan;97(1):29-36.

Early outcomes from a randomized, controlled trial of supervised exercise, angioplasty, and combined therapy in intermittent claudication. Mazari FA, Gulati S, Rahman MN, Lee HL, Mehta TA, McCollum PT, Chetter IC. Ann Vasc Surg. 2010 Jan;24(1):69-79.

Statins and ischaemia reperfusion injury: a molecular biological review. Abdul Rahman MN, Chetter IC. Curr Vasc Pharmacol. 2010 Nov;8(6):831-5.

2009

Kinematic gait adaptations in unilateral transtibial amputees during rehabilitation.Barnett C, Vanicek N, Polman R, Hancock A, Brown B, Smith L, Chetter I. Prosthet Orthot Int. 2009 Jun;33(2):135-47.

Randomized clinical trial of concomitant or sequential phlebectomy after endovenous laser therapy for varicose veins. Carradice D, Mekako AI, Hatfield J, Chetter IC. Br J Surg. 2009 Apr;96(4):369-75.

Quality of life in patients with lower limb ischemia; revised suggestions for analysis.Gulati S, Coughlin PA, Hatfield J, Chetter IC. J Vasc Surg. 2009 Jan;49(1):122-6.

2008

Nurse-led risk assessment/management clinics reduce predicted cardiac morbidity and mortality in claudicants. Hatfield J, Gulati S, Abdul Rahman MN, Coughlin PA, Chetter IC. J Vasc Nurs. 2008 Dec;26(4):118-22.

Peak wall stress measurement in elective and acute abdominal aortic aneurysms.Heng MS, Fagan MJ, Collier JW, Desai G, McCollum PT, Chetter IC. J Vasc Surg. 2008 Jan;47(1):17-22; discussion 22.

2007

Cutaneous hyperpigmentation after endovenous laser therapy: a case report and literature review. Mekako A, Chetter I. Ann Vasc Surg. 2007 Sep;21(5):637-9.

Plasma tissue factor is a predictor for restenosis after femoropopliteal angioplasty. Ray B, Chetter IC, Lee HL, Ettelaie C, McCollum PT. Br J Surg. 2007 Sep;94(9):1092-5.

A non-randomised controlled trial of the clinical and cost effectiveness of a Supervised Exercise Programme for claudication. Lee HL, Mehta T, Ray B, Heng MS, McCollum PT, Chetter IC. Eur J Vasc Endovasc Surg. 2007 Feb;33(2):202-7.

Differential functions of tissue factor in the trans-activation of cellular signalling pathways. Ettelaie C, Li C, Collier ME, Pradier A, Frentzou GA, Wood CG, Chetter IC, McCollum PT, Bruckdorfer KR, James NJ. Atherosclerosis. 2007 Sep;194(1):88-101.

 2006

 Combined endovenous laser therapy and ambulatory phlebectomy: refinement of a new technique. Mekako A, Hatfield J, Bryce J, Heng M, Lee D, McCollum P, Chetter I. Eur J Vasc Endovasc Surg. 2006 Dec;32(6):725-9.

A nonrandomised controlled trial of endovenous laser therapy and surgery in the treatment of varicose veins. Mekako AI, Hatfield J, Bryce J, Lee D, McCollum PT, Chetter I. Ann Vasc Surg. 2006 Jul;20(4):451-7.

Randomized clinical trial comparing multiple stab incision phlebectomy and transilluminated powered phlebectomy for varicose veins. Chetter IC, Mylankal KJ, Hughes H, Fitridge R. Br J Surg. 2006 Feb;93(2):169-74.

Assessing the validity and responsiveness of disease-specific quality of life instruments in intermittent claudication.Mehta T, Venkata Subramaniam A, Chetter I, McCollum P. Eur J Vasc Endovasc Surg. 2006 Jan;31(1):46-52.

2005

Heat shock proteins in vascular disease--a review. Mehta TA, Greenman J, Ettelaie C, Venkatasubramaniam A, Chetter IC, McCollum PT. Eur J Vasc Endovasc Surg. 2005 Apr;29(4):395-402.

2004

A comparative study of aortic wall stress using finite element analysis for ruptured and non-ruptured abdominal aortic aneurysms. Venkatasubramaniam AK, Fagan MJ, Mehta T, Mylankal KJ, Ray B, Kuhan G, Chetter IC, McCollum PT. Eur J Vasc Endovasc Surg. 2004 Aug;28(2):168-76.

The value of abdominal examination in the diagnosis of abdominal aortic aneurysm.Venkatasubramaniam AK, Mehta T, Chetter IC, Bryce J, Renwick P, Johnson B, Wilkinson A, McCollum PT. Eur J Vasc Endovasc Surg. 2004 Jan;27(1):56-60.

2003

Functional outcomes and quality of life in peripheral arterial disease: current status.Nehler MR, McDermott MM, Treat-Jacobson D, Chetter I, Regensteiner JG. Vasc Med. 2003 May;8(2):115-26.

Disease-specific quality of life assessment in intermittent claudication: review. Mehta T, Venkata Subramaniam A, Chetter I, McCollum P. Eur J Vasc Endovasc Surg. 2003 Mar;25(3):202-8.

2002

A Bayesian hierarchical approach to comparative audit for carotid surgery.Kuhan G, Marshall EC, Abidia AF, Chetter IC, McCollum PT. Eur J Vasc Endovasc Surg. 2002 Dec;24(6):505-10

How effective is acute normovolaemic haemodilution in femoro-distal bypass surgery? Spark JI, Chetter IC, Kester RC, Scott DJ. Cardiovasc Surg. 2002 Oct;10(5):460-3.

POSSUM and P-POSSUM overpredict mortality for carotid endarterectomy. Kuhan G, Abidia AF, Wijesinghe LD, Chetter IC, Johnson BF, Wilkinson AR, Renwick PM, McCollum PT. Eur J Vasc Endovasc Surg. 2002 Mar;23(3):209-11.

2001

Risk modelling study for carotid endarterectomy. Kuhan G, Gardiner ED, Abidia AF, Chetter IC, Renwick PM, Johnson BF, Wilkinson AR, McCollum PT. Br J Surg. 2001 Dec;88(12):1590-4.

The consequences of an abdominal aortic aneurysm infected with methicillin-resistant Staphylococcus aureus (MRSA). Chaudhary N, Dyde R, Chetter IC, Johnson BF. Eur J Vasc Endovasc Surg. 2001 Dec;22(6):568-9.

The analysis of sensitivity, specificity, positive predictive value and negative predictive value of cold provocation thermography in the objective diagnosis of the hand-arm vibration syndrome. Coughlin PA, Chetter IC, Kent PJ, Kester RC. Occup Med (Lond). 2001 Mar;51(2):75-80.

2000 and prior

Vascular surgical society of great britain and ireland: analysis of cold provocation thermography in the objective diagnosis of the hand-arm vibration syndrome. Coughlin P, Chetter IC, Kent PJ, Kester RC. Br J Surg. 1999 May;86(5):694-5.

Does soluble intercellular adhesion molecule-1 (ICAM-1) affect neutrophil activation and adhesion following ischaemia-reperfusion? Spark JI, Scott DJ, Chetter IC, Guillou PJ, Kester RC.Eur J Vasc Endovasc Surg. 1999 Feb;17(2):115-20.

Percutaneous transluminal angioplasty for intermittent claudication: evidence on which to base the medicine. Chetter IC, Spark JI, Kent PJ, Berridge DC, Scott DJ, Kester RC. Eur J Vasc Endovasc Surg. 1998 Dec;16(6):477-84.

Does angioplasty improve the quality of life for claudicants?: A prospective study.Chetter IC, Spark JI, Scott DJ, Kester RC. Ann Vasc Surg. 1999 Jan;13(1):93-103.

Prospective analysis of quality of life in patients following infrainguinal reconstruction for chronic critical ischaemia. Chetter IC, Spark JI, Scott DJ, Kent PJ, Berridge DC, Kester RC. Br J Surg. 1998 Jul;85(7):951-5.

The hand arm vibration syndrome: a review.Chetter IC, Kent PJ, Kester RC. Cardiovasc Surg. 1998 Feb;6(1):1-9.

An introduction to quality of life analysis: the new outcome measure in vascular surgery. Chetter IC, Scott DJ, Kester RC. Eur J Vasc Endovasc Surg. 1998 Jan;15(1):4-6.

Reduced total antioxidant capacity predicts ischaemia-reperfusion injury after femorodistal bypass. Spark JI, Chetter IC, Gallavin L, Kester RC, Guillou PJ, Scott DJ. Br J Surg. 1998 Feb;85(2):221-5.

Allogeneic versus autologous blood during abdominal aortic aneurysm surgery. Spark JI, Chetter IC, Kester RC, Scott DJ. Eur J Vasc Endovasc Surg. 1997 Dec;14(6):482-6.

Correlating clinical indicators of lower-limb ischaemia with quality of life. Chetter IC, Dolan P, Spark JI, Scott DJ, Kester RC. Cardiovasc Surg. 1997 Aug;5(4):361-6.

Quality of life analysis in patients with lower limb ischaemia: suggestions for European standardisation. Chetter IC, Spark JI, Dolan P, Scott DJ, Kester RC. Eur J Vasc Endovasc Surg. 1997 Jun;13(6):597-604.

The regulation of neutrophil activation and adhesion during femorodistal bypass surgery. Spark JI, Chetter IC, Kester RC, Guillou PJ, Scott DJ. Eur J Vasc Endovasc Surg. 1997 Apr;13(4):407-12.

Limb threatening ischaemia. Chetter IC. Eur J Vasc Endovasc Surg. 1995 Oct;10(3):385-6.