Professor Clark is the head of the department of Academic Cardiology, one of the leading institutions for research in heart failure in Europe.
Professor Clark was educated at Pembroke College, Cambridge, and trained in medicine at the Westminster Medical School. He trained in cardiology at Manchester Royal Infirmary, the National Heart and Lung Institute (London) and the Western Infirmary, Glasgow.
He became a Senior Lecturer in cardiology in the University of Hull in 1999 and was promoted to Reader in 2004 and then Professor in 2009. He is responsible for running the echocardiography service in Hull, and he plays an active role in the day-to-day provision of cardiology services to the population of Hull and the East Riding of Yorkshire.
He is Chair of the British Society for Heart Failure, and is a member of the working groups for Heart Failure and Cardiac Rehabilitation and Exercise Physiology in the European Society of Cardiology.
Whilst at the National Heart and Lung Institute, under the guidance of Philip Poole-Wilson and Andrew Coats, Professor Clark developed an interest in exercise physiology, particularly in patients with heart failure. He is interested in the natural history of heart failure and runs the largest database of patients with heart failure in Europe allowing the tracking of large numbers of patients. More recently, he has become interested in palliative care and the alleviation of symptoms for patients in the last stages of their illness.
Professor Clark lectures all the years in HYMS, mainly on cardiovascular medicine. He takes a group of third years and is responsible for making certain that they can read an ECG before they leave!
Professor Clark has published over 300 papers, predominantly in the general area of heart failure, but including some work on contraception in primary care! Recent papers in include:
Hobkirk JP, Damy T, Walters M, Bennett A, Smith SJ, Ingle L, Clark AL, Cleland JG. Effects of reducing inspired oxygen concentration for one hour in patients with chronic heart failure: implications for air travel. Eur J Heart Fail 2013;15: 505-12
Pellicori P, Carubelli V, Zhang J, Castiello T, Sherwi N, Clark AL, Cleland JG. IVC diameter in patients with chronic heart failure: relationships and prognostic significance. JACC Cardiovasc Imaging 2013;6:16-28
Oxberry SG, Bland JM, Clark AL, Cleland JG, Johnson MJ. Repeat dose opioids may be effective for breathlessness in chronic heart failure if given for long enough. J Palliat Med2013;16:250-5
Pellicori P, Kallvikbacka-Bennett A, Khaleva O, Carubelli V, Costanzo P, Castiello T, Wong K, Zhang J, Cleland JG, Clark AL. Global longitudinal strain in patients with suspected heart failure and a normal ejection fraction: does it improve diagnosis and risk stratification? Int J Cardiovasc Imaging2014;30:69-79
Zachariah D, Brown R, Kanagala P, Bashir A, Mohan M, Callan P, Rajendra R, Clark AL, Squire I, Gunning M, Lang CC, Kalra PR. The impact of age and chronic kidney disease on secondary prevention post-primary percutaneous coronary intervention. QJM2014;107:185-92Wong HT, Clark AL. Impact of reported sexual dysfunction on outcome in patients with chronic heart failure. Int J Cardiol2013;170:e48-50
Pellicori P, Kallvikbacka-Bennett A, Zhang J, Khaleva O, Warden J, Clark AL, Cleland JG. Revisiting a classical clinical sign: Jugular venous ultrasound. Int J Cardiol 2014;170:364-70 [Epub ahead of print]
Goode KM, Nicholls R, Pellicori P, Clark AL, Cleland JG. The in vitro stability of novel cardiovascular and sepsis biomarkers at ambient temperature. Clin Chem Lab Med2014 Jan 9:1-8. doi: 10.1515/cclm-2013-0767
Ingle L, Rigby AS, Sloan R, Carroll S, Goode KM, Cleland JG, Clark AL. Development of a composite model derived from cardiopulmonary exercise tests to predict mortality risk in patients with mild-to-moderate heart failure. Heart 2014:100:781-6
Ingle L, Cleland JG, Clark AL. The long-term prognostic significance of 6-minute walk test distance in patients with chronic heart failure. Biomed Res Int 2014;2014:505969. doi: 10.1155/2014/505969
Ingle L, Cleland JG, Clark AL. The relation between repeated 6-minute walk test performance and outcome in patients with chronic heart failure. Ann Phys Rehabil Med2014;57:244-53
Cullington D, Goode KM, Zhang J, Cleland JG, Clark AL. Is heart rate important for patients with heart failure in atrial fibrillation? JACC Heart Fail 2014;2:213-20