Professor Andrew Clark


Chair in Clinical Cardiology

Role at Hull York Medical School

Professor Clark is the head of the department of Academic Cardiology, one of the leading institutions for research in heart failure in Europe.


Professor Clark was educated at Pembroke College, Cambridge, and trained in medicine at the Westminster Medical School. He trained in cardiology at Manchester Royal Infirmary, the National Heart and Lung Institute (London) and the Western Infirmary, Glasgow.

He became a Senior Lecturer in cardiology in the University of Hull in 1999 and was promoted to Reader in 2004 and then Professor in 2009. He is responsible for running the echocardiography service in Hull, and he plays an active role in the day-to-day provision of cardiology services to the population of Hull and the East Riding of Yorkshire. 

He is Chair of the British Society for Heart Failure, and is a member of the working groups for Heart Failure and Cardiac Rehabilitation and Exercise Physiology in the European Society of Cardiology.


Whilst at the National Heart and Lung Institute, under the guidance of Philip Poole-Wilson and Andrew Coats, Professor Clark developed an interest in exercise physiology, particularly in patients with heart failure. He is interested in the natural history of heart failure and runs the largest database of patients with heart failure in Europe allowing the tracking of large numbers of patients. More recently, he has become interested in palliative care and the alleviation of symptoms for patients in the last stages of their illness. 


Professor Clark lectures all the years in HYMS, mainly on cardiovascular medicine. He takes a group of third years and is responsible for making certain that they can read an ECG before they leave!


Professor Clark has published over 300 papers, predominantly in the general area of heart failure, but including some work on contraception in primary care! Recent papers in include: 

Prevalence, predictors, and prognostic implications of PR interval prolongation in patients with heart failure.
Nikolaidou T, Pellicori P, Zhang J, Kazmi S, Goode KM, Cleland JG, Clark AL.
Clin Res Cardiol 2018;107:108-119

The utility of myocardial perfusion imaging before renal transplantation: a retrospective analysis.
Callan PD, Bhandari S, Clark AL, Eadington D, Papadopoulos E, Tweddel AC.
Nucl Med Commun 2018 Jan 2. doi: 10.1097/MNM.0000000000000793.

Prognostic value of psychosocial factors for first and recurrent hospitalizations and mortality in heart failure patients: insights from the OPERA-HF study.
Sokoreli I, Pauws SC, Steyerberg EW, de Vries GJ, Riistama JM, Tesanovic A, Kazmi S, Pellicori P, Cleland JG, Clark AL.
Eur J Heart Fail 2018 Jan 4. doi: 10.1002/ejhf.1112.

Post-mortem ICD interrogation in mode of death classification.
Nikolaidou T, Johnson MJ, Ghosh JM, Marincowitz C, Shah S, Lammiman MJ, Schilling RJ, Clark AL.
J Cardiovasc Electrophysiol 2018 Jan 8. doi: 10.1111/jce.13414.

Clinical and prognostic relationships of pulmonary artery to aorta diameter ratio in patients with heart failure: a cardiac magnetic resonance imaging study.
Pellicori P, Urbinati A, Zhang J, Joseph AC, Costanzo P, Lukaschuk E, Capucci A, Cleland JGF, Clark AL.
Clin Cardiol 2018;41: DOI: 10.1002/clc.22840

CARE CR-Cardiovascular and cardiorespiratory Adaptations to Routine Exercise-based Cardiac Rehabilitation: a study protocol for a community-based controlled study with criterion methods.
Nichols S, Nation F, Goodman T, Clark AL, Carroll S, Ingle L.
BMJ Open 2018;8:e019216. doi: 10.1136/bmjopen-2017-019216

Telemonitoring in subjects with newly diagnosed heart failure with reduced ejection fraction: From clinical research to everyday practice.
Koulaouzidis G, Barrett D, Mohee K, Clark AL.
J Telemed Telecare 2018: doi: 10.1177/1357633X17751004

Effect of beta-adrenergic blockade on weight changes in patients with chronic heart failure.
Sze S, Pellicori P, Kamzi S, Anton A, Clark AL.
Int J Cardiol 2018 doi: 10.1016/j.ijcard.2018.03.089.

Cardiogoniometry compared to fractional flow reserve at identifying physiologically significant coronary stenosis: the CARDIOFLOW study.
Brown OI, Clark AL, Chelliah R, Davison BJ, Mather AN, Cunnington MS, John J, Alahmar A, Oliver R, Aznaouridis K, Hoye A.
Cardiovasc Eng Technol 2018: doi: 10.1007/s13239-018-0354-1

Prevalence and prognostic significance of malnutrition using 3 scoring systems among outpatients with heart failure: a comparison with body mass index.
Sze S, Pellicori P, Kazmi S, Rigby A, Cleland JGF, Wong K, Clark AL.
JACC Heart Fail 2018 May 2. pii: S2213-1779(18)30223-3. doi: 10.1016/j.jchf.2018.02.018.

Is cardiorespiratory fitness related to cardiometabolic health and all-cause mortality risk in patients with coronary heart disease? A CARE CR Study.
Nichols S, Taylor C, Page R, Kallvikbacka-Bennett A, Nation F, Goodman T, Clark AL, Carroll S, Ingle L.
Sports Med Open 2018;4:22. doi: 10.1186/s40798-018-0138-z

Validation of U.S. mortality prediction models for hospitalized heart failure in the United Kingdom and Japan.
Nagai T, Sundaram V, Shoaib A, Shiraishi Y, Kohsaka S, Rothnie KJ, Piper S, McDonagh TA, Hardman SMC, Goda A, Mizuno A, Sawano M, Rigby AS, Quint JK, Yoshikawa T, Clark AL, Anzai T, Cleland JGF.
Eur J Heart Fail 2018 May 30. doi: 10.1002/ejhf.1210.

Effect of increased inspired oxygen on exercise performance in patients with heart failure and normal ejection fraction.
Shah P, Pellicori P, Rimmer S, Rigby AS, Clark AL.
Int J Cardiol 2018 doi: 10.1016/j.ijcard.2018.05.029.

Outcome of hospitalised heart failure in Japan and the United Kingdom stratified by plasma N-terminal pro-B-type natriuretic peptide.
Shiraishi Y, Nagai T, Kohsaka S, Goda A, Nagatomo Y, Mizuno A, Kohno T, Rigby A, Fukuda K, Yoshikawa T, Clark AL, Cleland JGF.
Clin Res Cardiol 2018 doi: 10.1007/s00392-018-1283-6.

Low serum chloride in patients with chronic heart failure: clinical associations and prognostic significance.
Cuthbert JJ, Pellicori P, Rigby A, Pan D, Kazmi S, Shah P, Clark AL.
Eur J Heart Fail 2018 Jun 26. doi: 10.1002/ejhf.1247.

Body mass index and all-cause mortality in heart failure patients with normal and reduced ventricular ejection fraction: a dose-response meta-analysis.
Zhang J, Begley A, Jackson R, Harrison M, Pellicori P, Clark AL, Cleland JGF.
Clin Res Cardiol 2018 Jun 27. doi: 10.1007/s00392-018-1302-7

Dynamic risk stratification using serial measurements of plasma concentrations of natriuretic peptides in patients with heart failure.
Zhang J, Pellicori P, Pan D, Dierckx R, Clark AL, Cleland JGF.
Int J Cardiol 2018 Jun 25. pii: S0167-5273(17)37429-6. doi: 10.1016/j.ijcard.2018.06.070.

The HF-CGM Study: an analysis of cardiogoniometric axes in patients with cardiac resynchronization therapy.
Brown OI, Nikolaidou T, Beddoes G, Hoye A, Clark AL.
IEEE Trans Biomed Eng 2018;65:1711-1716

The impact of heart failure and chronic obstructive pulmonary disease on mortality in patients presenting with breathlessness.
Cuthbert JJ, Kearsley JW, Kazmi S, Kallvikbakka-Bennett A, Weston J, Davis J, Rimmer S, Clark AL.
Clin Res Cardiol 2018 Aug 8. doi: 10.1007/s00392-018-1342-z.

Malnutrition, congestion and mortality in ambulatory patients with heart failure.
Sze S, Pellicori P, Zhang J, Clark AL.
Heart 2018 doi: 10.1136/heartjnl-2018-313312.

Low skeletal muscle mass is associated with low aerobic capacity and increased mortality risk in patients with coronary heart disease – a CARE CR study.
Nichols S, O’Doherty AF, Taylor C, Clark AL, Carroll S, Ingle L.
Clin Physiol Funct Imaging 2018 doi: 10.1111/cpf.12539

Warm water immersion in patients with chronic heart failure: a pilot study.
Shah P, Pellicori P, Kallvikbacka-Bennett A, Zhang J, Pan D, Clark AL.
Clin Res Cardiol 2018 Sep 28. doi: 10.1007/s00392-018-1376-2.

Mortality after admission for heart failure in the UK compared with Japan.
Nagai T, Sundaram V, Rothnie K, Quint JK, Shoaib A, Shiraishi Y, Kohsaka S, Piper S, McDonagh TA, Hardman SMC, Goda A, Mizuno A, Kohno T, Rigby AS, Yoshikawa T, Clark AL, Anzai T, Cleland JGF.
Open Heart 2018;5:e000811. doi: 10.1136/openhrt-2018-000811