Professor Chetter’s interests are predominantly Health Services Research and New & Emerging Technologies in arterial and venous disease, wound healing and surgical site infection. In addition he has interests in the molecular biology of aneurysmal disease, ishaemia reperfusion, translational research in therapies for intermittent claudication and educational research analyzing the value of endovascular simulation.
i) Endovenous therapies for lower limb superficial venous incompetence
ii) Evaluating the benefits and mechanism of supervised exercise in claudicants
iii) Surgical wounds healing by secondary intention
iv) ACE inhibitors in claudicants
v) Endovascular simulation in vascular surgical training
vi) Clinical and histopathological factors affecting patency of arteriovenous fistulae
vii) Cardiovascular physiology in patients undergoing aortic aneurysm repair
viii) Fibrin sealants in arterial surgery
ix) Surgical site infection in clean surgery
NIHR programme grant (PI) – Surgical Wounds healing by secondary intention (2011 – 2016)
HTA CLASS Trial (local PI) – RCT of laser, surgery and sclerotherapy in the management of varicose veins (2009 -2012)
HTA IMPROVE Trial (local PI) – RCT of open and endovascular repair of ruptured AAA (2010 -2013)
Yorkshire Vascular Surgical Research Fund- equipment grant (2011)
Instituto Grifols (local PI) – RCT of fibrin sealant in arterial surgery (2010 – 2012)
Pfizer AMPLFY – ext trial (local PI) – RCT of extended anticoagulation in thromboembolic disease (2010 – 2011)
Postgraduate; appointed Vascular Tutor RCS England (Feb 2010)
-responsible for the national provision of Vascular Courses.
- evaluated and revised current courses including cognitive & affective (decision making) learning and introduced assessment
- developed 2 new courses in direct response to identified deficiencies (Vascular Access & Modern Management of Varicose veins)
- all courses fully subscribed & received exceptional feedback
- supervisor for PG Cert Med US
- major contribution to development of undergraduate RCS courses (Anatomy Summer school & Surgical Skills for Students)
- Phase 1 clinical placement tutor & Phase 3 tutor
- Contributed to development & provision of HAiRT course
- iBSc supervisor
- developed & provided SSC’s
Developing teaching skills in others
- supervise & support research fellow undertaking MClinEd.
- all research fellows undergo formal HYMS training in teaching and assessment.
- 1st, 2nd, 4th & 5th year HYMS students
- internal examiner for the University of Hull
- external examiner for Universities of Newcastle & Leeds
- Regional HST committee member (RITA & ARCP)
- currently evaluating validy, reliability and responsiveness of PBA in caderveric courses
- developing assessment instrument for use in simulated evironment
- assessing the value of endovascular simulation in vascular trainees
F A K Mazari, J A Khan, D Carradice, N Samuel, M N A Abdulrahman, S Gulati, H L D Lee, T A Mehta, P T McCollum, I C Chetter
Randomized clinical trial of percutaneous transluminal angioplasty, supervised exercise and combined treatment for intermittent claudication due to femoropopliteal arterial disease
British Journal of Surgery January 2012 99(1) 39-48 Doi:10.1002/bjs.7710
L A Green, I C Chetter
Procedure based assessments: an evaluation of their role in reflective learning
Annals of Royal College of Surgeons of England January 2012 94: (Suppl) 28-31
Y Shahin, J A Khan, I Chetter
Angiotensin converting enzyme inhibitors effect arterial stiffness and wave reflections: A meta –analysis and meta-regression of randomised controlled trials
Atherosclerosis March 12 221 (1): 18-33 Doi:10.1016/j.atherosclerosis.2011.12.005
G E Smith, R Gohil, I Chetter
Factors affecting the patency of arteriovenous fistulae for dialysis access
Journal of Vascular Surgery March 12 55 (3): 849-855 Doi:10.1016/j.jvs.2011.07.095
N Samuel, D Carradice, A I Mekako, T Wallace, J Hatfield, I C Chetter
Randomised trial of endovenous laser ablation versus surgery for small saphenous varicose veins
British Journal of Surgery March 12 99 (S3): 13 Doi:10.1002/bjs.8725
Comparing the treatment response of great saphenous and small saphenous vein incompetence following surgery and endovenous laser ablation: a retrospective cohort study. Carradice D, Samuel N, Wallace T, Mazari FA, Hatfield J, Chetter I. Phlebology. 2011 Aug 3. [Epub ahead of print]
Patients' Perspective of Functional Outcome After Elective Abdominal Aortic Aneurysm Repair: A Questionnaire Survey.Khan JA, Mazari FA, Abdul Rahman MN, Mockford K, Chetter IC, McCollum PT. Ann Vasc Surg. 2011 Jul 27. [Epub ahead of print]
Great saphenous vein transposition to the forearm for dialysis vascular access; an under used autologous option? Smith GE, Carradice D, Samuel N, Gohil R, Chetter IC. J Vasc Access. 2011 Jun 1. [Epub ahead of print]
Targeted Duplex Ultrasound in a One-Stop Dialysis Vascular Access Assessment Clinic. Smith GE, Samuel N, Khan J, Johnson BF, Chetter IC. Ann Vasc Surg. 2011 Jun 11. [Epub ahead of print]
Clinical and technical outcomes from a randomized clinical trial of endovenous laser ablation compared with conventional surgery for great saphenous varicose veins. Carradice D, Mekako AI, Mazari FA, Samuel N, Hatfield J, Chetter IC. Br J Surg. 2011 Aug;98(8):1117-23.
Modelling the effect of venous disease on quality of life. Carradice D, Mazari FA, Samuel N, Allgar V, Hatfield J, Chetter IC. Br J Surg. 2011 Aug;98(8):1089-98.
Angiotensin converting enzyme inhibitors effect on endothelial dysfunction: a meta-analysis of randomised controlled trials.Shahin Y, Khan JA, Samuel N, Chetter I. Atherosclerosis. 2011 May;216(1):7-16.
Randomized clinical trial of endovenous laser ablation compared with conventional surgery for great saphenous varicose veins. Carradice D, Mekako AI, Mazari FA, Samuel N, Hatfield J, Chetter IC. Br J Surg. 2011 Apr;98(4):501-10.
Do angiotensin converting enzyme inhibitors improve walking distance in patients with symptomatic lower limb arterial disease? A systematic review and meta-analysis of randomised controlled trials. Shahin Y, Mazari F, Chetter I. Int J Surg. 2011;9(3):209-13.
A randomized placebo controlled trial of the effect of preoperative statin use on matrix metalloproteinases and tissue inhibitors of matrix metalloproteinases in areas of low and peak wall stress in patients undergoing elective open repair of abdominal aortic aneurysm. Rahman MN, Khan JA, Mazari FA, Mockford K, McCollum PT, Chetter IC. Ann Vasc Surg. 2011 Jan;25(1):32-8.
Computerized dynamic posturography in the objective assessment of balance in patients with intermittent claudication.Mockford KA, Mazari FA, Jordan AR, Vanicek N, Chetter IC, Coughlin PA. Ann Vasc Surg. 2011 Feb;25(2):182-90.
Hull early walking aid for rehabilitation of transtibial amputees--randomized controlled trial (HEART). Mazari FA, Mockford K, Barnett C, Khan JA, Brown B, Smith L, Polman RC, Hancock A, Vanicek NK, Chetter IC. J Vasc Surg. 2010 Dec;52(6):1564-71.
Randomized clinical trial of tranexamic acid-free fibrin sealant during vascular surgical procedures. Chalmers RT, Darling Iii RC, Wingard JT, Chetter I, Cutler B, Kern JA, Hart JC. Br J Surg. 2010 Dec;97(12):1784-9.
Obstacles in initiating a new research project--reflection on medical research in UK. Khan JA, Mazari FA, Chetter IC, McCollum PT. Int J Surg. 2010;8(8):656-7.
Kinematic adaptations to ischemic pain in claudicants during continuous walking.Mockford KA, Vanicek N, Jordan A, Chetter IC, Coughlin PA. Gait Posture. 2010 Jul;32(3):395-9.
Energy delivery during 810 nm endovenous laser ablation of varicose veins and post-procedural morbidity. Carradice D, Mazari FA, Mekako A, Hatfield J, Allgar V, Chetter IC. Eur J Vasc Endovasc Surg. 2010 Sep;40(3):393-8.
An analysis of relationship between quality of life indices and clinical improvement following intervention in patients with intermittent claudication due to femoropopliteal disease. Mazari FA, Carradice D, Rahman MN, Khan JA, Mockford K, Mehta T, McCollum PT, Chetter IC. J Vasc Surg. 2010 Jul;52(1):77-84.
Randomized clinical trial of co-amoxiclav versus no antibiotic prophylaxis in varicose vein surgery. Mekako AI, Chetter IC, Coughlin PA, Hatfield J, McCollum PT; Hull Antibiotic pRophylaxis in varicose Vein Surgery Trialists (HARVEST). Br J Surg. 2010 Jan;97(1):29-36.
Early outcomes from a randomized, controlled trial of supervised exercise, angioplasty, and combined therapy in intermittent claudication. Mazari FA, Gulati S, Rahman MN, Lee HL, Mehta TA, McCollum PT, Chetter IC. Ann Vasc Surg. 2010 Jan;24(1):69-79.
Statins and ischaemia reperfusion injury: a molecular biological review. Abdul Rahman MN, Chetter IC. Curr Vasc Pharmacol. 2010 Nov;8(6):831-5.
Kinematic gait adaptations in unilateral transtibial amputees during rehabilitation.Barnett C, Vanicek N, Polman R, Hancock A, Brown B, Smith L, Chetter I. Prosthet Orthot Int. 2009 Jun;33(2):135-47.
Randomized clinical trial of concomitant or sequential phlebectomy after endovenous laser therapy for varicose veins. Carradice D, Mekako AI, Hatfield J, Chetter IC. Br J Surg. 2009 Apr;96(4):369-75.
Quality of life in patients with lower limb ischemia; revised suggestions for analysis.Gulati S, Coughlin PA, Hatfield J, Chetter IC. J Vasc Surg. 2009 Jan;49(1):122-6.
Nurse-led risk assessment/management clinics reduce predicted cardiac morbidity and mortality in claudicants. Hatfield J, Gulati S, Abdul Rahman MN, Coughlin PA, Chetter IC. J Vasc Nurs. 2008 Dec;26(4):118-22.
Peak wall stress measurement in elective and acute abdominal aortic aneurysms.Heng MS, Fagan MJ, Collier JW, Desai G, McCollum PT, Chetter IC. J Vasc Surg. 2008 Jan;47(1):17-22; discussion 22.
Cutaneous hyperpigmentation after endovenous laser therapy: a case report and literature review. Mekako A, Chetter I. Ann Vasc Surg. 2007 Sep;21(5):637-9.
Plasma tissue factor is a predictor for restenosis after femoropopliteal angioplasty. Ray B, Chetter IC, Lee HL, Ettelaie C, McCollum PT. Br J Surg. 2007 Sep;94(9):1092-5.
A non-randomised controlled trial of the clinical and cost effectiveness of a Supervised Exercise Programme for claudication. Lee HL, Mehta T, Ray B, Heng MS, McCollum PT, Chetter IC. Eur J Vasc Endovasc Surg. 2007 Feb;33(2):202-7.
Differential functions of tissue factor in the trans-activation of cellular signalling pathways. Ettelaie C, Li C, Collier ME, Pradier A, Frentzou GA, Wood CG, Chetter IC, McCollum PT, Bruckdorfer KR, James NJ. Atherosclerosis. 2007 Sep;194(1):88-101.
Combined endovenous laser therapy and ambulatory phlebectomy: refinement of a new technique. Mekako A, Hatfield J, Bryce J, Heng M, Lee D, McCollum P, Chetter I. Eur J Vasc Endovasc Surg. 2006 Dec;32(6):725-9.
A nonrandomised controlled trial of endovenous laser therapy and surgery in the treatment of varicose veins. Mekako AI, Hatfield J, Bryce J, Lee D, McCollum PT, Chetter I. Ann Vasc Surg. 2006 Jul;20(4):451-7.
Randomized clinical trial comparing multiple stab incision phlebectomy and transilluminated powered phlebectomy for varicose veins. Chetter IC, Mylankal KJ, Hughes H, Fitridge R. Br J Surg. 2006 Feb;93(2):169-74.
Assessing the validity and responsiveness of disease-specific quality of life instruments in intermittent claudication.Mehta T, Venkata Subramaniam A, Chetter I, McCollum P. Eur J Vasc Endovasc Surg. 2006 Jan;31(1):46-52.
Heat shock proteins in vascular disease--a review. Mehta TA, Greenman J, Ettelaie C, Venkatasubramaniam A, Chetter IC, McCollum PT. Eur J Vasc Endovasc Surg. 2005 Apr;29(4):395-402.
A comparative study of aortic wall stress using finite element analysis for ruptured and non-ruptured abdominal aortic aneurysms. Venkatasubramaniam AK, Fagan MJ, Mehta T, Mylankal KJ, Ray B, Kuhan G, Chetter IC, McCollum PT. Eur J Vasc Endovasc Surg. 2004 Aug;28(2):168-76.
The value of abdominal examination in the diagnosis of abdominal aortic aneurysm.Venkatasubramaniam AK, Mehta T, Chetter IC, Bryce J, Renwick P, Johnson B, Wilkinson A, McCollum PT. Eur J Vasc Endovasc Surg. 2004 Jan;27(1):56-60.
Functional outcomes and quality of life in peripheral arterial disease: current status.Nehler MR, McDermott MM, Treat-Jacobson D, Chetter I, Regensteiner JG. Vasc Med. 2003 May;8(2):115-26.
Disease-specific quality of life assessment in intermittent claudication: review. Mehta T, Venkata Subramaniam A, Chetter I, McCollum P. Eur J Vasc Endovasc Surg. 2003 Mar;25(3):202-8.
A Bayesian hierarchical approach to comparative audit for carotid surgery.Kuhan G, Marshall EC, Abidia AF, Chetter IC, McCollum PT. Eur J Vasc Endovasc Surg. 2002 Dec;24(6):505-10
How effective is acute normovolaemic haemodilution in femoro-distal bypass surgery? Spark JI, Chetter IC, Kester RC, Scott DJ. Cardiovasc Surg. 2002 Oct;10(5):460-3.
POSSUM and P-POSSUM overpredict mortality for carotid endarterectomy. Kuhan G, Abidia AF, Wijesinghe LD, Chetter IC, Johnson BF, Wilkinson AR, Renwick PM, McCollum PT. Eur J Vasc Endovasc Surg. 2002 Mar;23(3):209-11.
Risk modelling study for carotid endarterectomy. Kuhan G, Gardiner ED, Abidia AF, Chetter IC, Renwick PM, Johnson BF, Wilkinson AR, McCollum PT. Br J Surg. 2001 Dec;88(12):1590-4.
The consequences of an abdominal aortic aneurysm infected with methicillin-resistant Staphylococcus aureus (MRSA). Chaudhary N, Dyde R, Chetter IC, Johnson BF. Eur J Vasc Endovasc Surg. 2001 Dec;22(6):568-9.
The analysis of sensitivity, specificity, positive predictive value and negative predictive value of cold provocation thermography in the objective diagnosis of the hand-arm vibration syndrome. Coughlin PA, Chetter IC, Kent PJ, Kester RC. Occup Med (Lond). 2001 Mar;51(2):75-80.
2000 and prior
Vascular surgical society of great britain and ireland: analysis of cold provocation thermography in the objective diagnosis of the hand-arm vibration syndrome. Coughlin P, Chetter IC, Kent PJ, Kester RC. Br J Surg. 1999 May;86(5):694-5.
Does soluble intercellular adhesion molecule-1 (ICAM-1) affect neutrophil activation and adhesion following ischaemia-reperfusion? Spark JI, Scott DJ, Chetter IC, Guillou PJ, Kester RC.Eur J Vasc Endovasc Surg. 1999 Feb;17(2):115-20.
Percutaneous transluminal angioplasty for intermittent claudication: evidence on which to base the medicine. Chetter IC, Spark JI, Kent PJ, Berridge DC, Scott DJ, Kester RC. Eur J Vasc Endovasc Surg. 1998 Dec;16(6):477-84.
Does angioplasty improve the quality of life for claudicants?: A prospective study.Chetter IC, Spark JI, Scott DJ, Kester RC. Ann Vasc Surg. 1999 Jan;13(1):93-103.
Prospective analysis of quality of life in patients following infrainguinal reconstruction for chronic critical ischaemia. Chetter IC, Spark JI, Scott DJ, Kent PJ, Berridge DC, Kester RC. Br J Surg. 1998 Jul;85(7):951-5.
The hand arm vibration syndrome: a review.Chetter IC, Kent PJ, Kester RC. Cardiovasc Surg. 1998 Feb;6(1):1-9.
An introduction to quality of life analysis: the new outcome measure in vascular surgery. Chetter IC, Scott DJ, Kester RC. Eur J Vasc Endovasc Surg. 1998 Jan;15(1):4-6.
Reduced total antioxidant capacity predicts ischaemia-reperfusion injury after femorodistal bypass. Spark JI, Chetter IC, Gallavin L, Kester RC, Guillou PJ, Scott DJ. Br J Surg. 1998 Feb;85(2):221-5.
Allogeneic versus autologous blood during abdominal aortic aneurysm surgery. Spark JI, Chetter IC, Kester RC, Scott DJ. Eur J Vasc Endovasc Surg. 1997 Dec;14(6):482-6.
Correlating clinical indicators of lower-limb ischaemia with quality of life. Chetter IC, Dolan P, Spark JI, Scott DJ, Kester RC. Cardiovasc Surg. 1997 Aug;5(4):361-6.
Quality of life analysis in patients with lower limb ischaemia: suggestions for European standardisation. Chetter IC, Spark JI, Dolan P, Scott DJ, Kester RC. Eur J Vasc Endovasc Surg. 1997 Jun;13(6):597-604.
The regulation of neutrophil activation and adhesion during femorodistal bypass surgery. Spark JI, Chetter IC, Kester RC, Guillou PJ, Scott DJ. Eur J Vasc Endovasc Surg. 1997 Apr;13(4):407-12.
Limb threatening ischaemia. Chetter IC. Eur J Vasc Endovasc Surg. 1995 Oct;10(3):385-6.