Dr Ioannis Kourtzelis

Lecturer in Immunology

Role at Hull York Medical School

Lecturer in Immunology

Biography

Education

(2001 - 2006): B.S. in Biology, Faculty of Sciences, School of Biology, Aristotle Univ. of Thessaloniki, Greece.

(2007 - 2011): PhD, Univ. of Pennsylvania, USA / Democritus Univ. of Thrace, Greece. Ph.D. Dissertation: Inflammatory mediators in clinical models – Τhe regulatory role of C5a anaphylatoxin.

Employment record

(2020 - present): Lecturer in Immunology at HYMS of the University of York, United Kingdom.

(November 2013 – December 2019): Senior Post-doctoral Researcher at Technische Univ. Dresden, Germany, Faculty of Medicine, Institute for Clinical Chemistry & Lab. Medicine and National Center for Tumor Diseases, Partner Site Dresden.

(September 2011 – October 2013): Post-doctoral Researcher at Aristotle Univ. of Thessaloniki, Greece, Faculty of Science, School of Biology, Department of Genetics, Development & Molecular Biology

(2012): Adjunct lecturer (PD 407/80 position) at Aristotle University of Thessaloniki, Faculty of Science, School of Biology.

(May 2009 – May 2011): Visiting Research Scholar at University of Pennsylvania, School of Medicine,Philadelphia, PA, USA

Publications

33 publications in peer-reviewed journals

Pubmed link: https://www.ncbi.nlm.nih.gov/pubmed/?term=kourtzelis+i

Research

My research interests focus on the study of mechanisms that orchestrate the onset and resolution of sterile and pathogen-induced inflammation.

Publications

Selected original articles

DEL-1 promotes macrophage efferocytosis and clearance of inflammation.I. Kourtzelis*,§, X. Li*, I. Mitroulis, D. Grosser, T. Kajikawa, B. Wang, ... Ü. Coskun, G. Hajishengallis§, T. Chavakis§ *Equal contribution, §Correspondence author. Highlighted in Nat. Immunol. News & Views: (https://www.ncbi.nlm.nih.gov/pubmed/30538337)Nat. Immunol. (doi: 10.1038/s41590-018-0249-1)

I. Mitroulis, K. Ruppova*, B. Wang*, L.S. Chen*, M. Grzybek*, T. Grinenko, A. Eugster, M. Troullinaki, A. Palladini, I. Kourtzelis... U. Coskun, G. Hajishengallis, M.G.Netea, T. Chavakis *Equal contribution. Cell. 2018 Jan 11;172(1-2):147-161.e12. doi: 10.1016/j.cell.2017.11.034

The mevalonate pathway drives metabolic and epigenetic reprogramming during induction of trained immunity. Bekkering S*, Arts RJW*, Novakovic B, Kourtzelis I, van der Heijden CDCC ... Stunnenberg H, Riksen NP, Netea MG. *Equal contribution. Cell, 2018 Jan 11;172(1-2):135-146.e9. doi: 10.1016/j.cell.2017.11.025

Secreted protein Del-1 regulates myelopoiesis in the hematopoietic stem cell niche.Mitroulis I*, Chen LS*, Singh RP*, Kourtzelis I, Economopoulou M... Hidalgo A, Wielockx B, Hajishengallis G, Chavakis T. *Equal contribution. J Clin Invest. 2017 Oct 2;127(10):3624-3639. doi: 10.1172/JCI92571

Developmental endothelial locus-1 modulates platelet-monocyte interactions and instant blood- mediated inflammatory reaction in islet transplantation. Kourtzelis I*, Kotlabova K, Lim JH, Mitroulis I... Wolf E, Hajishengallis G, Chavakis T. *Correspondence author. Thromb Haemost. 2016 Apr 1;115(4):781-8

Complement deficiency promotes cutaneous wound healing in mice. Rafail S*, Kourtzelis I*, Foukas PG ... Ricklin D, Grice EA, Lambris JD. *Equal contribution. J Immunol. 2015 Feb 1;194(3):1285-91

Inhibition of biomaterial-induced complement activation attenuates the inflammatory host response to implantation. Kourtzelis I, Rafail S, DeAngelis RA, Foukas PG, Ricklin D, Lambris JD.FASEB J. 2013 Jul;27(7):2768-76

A complement-IL-4 regulatory circuit controls liver regeneration. DeAngelis RA*, Markiewski MM*, Kourtzelis I*, Rafail S*, Syriga M, Sandor A, Maurya MR, Gupta S, Subramaniam S, Lambris JD. *Equal contribution. J Immunol. 2012 Jan 15;188(2):641-8

Complement anaphylatoxin C5a contributes to hemodialysis-associated thrombosis.Kourtzelis I*, Markiewski MM*, Doumas M, Rafail S... Mollnes TE, Ritis K, Lambris JD. *Equal contribution. Blood. 2010 Jul 29;116(4):631-9. Highlighted by the american society of hematology (ASH News & Reports) and the national institute of biomedical imaging and bioengineering.

Regulation of the autophagic machinery in human neutrophils. Mitroulis I*, Kourtzelis I*, Kambas K, Rafail S, Chrysanthopoulou A, Speletas M, Ritis K. *Equal contribution. Eur J Immunol. 2010 May;40(5):1461-72

Selected Reviews

From leukocyte recruitment to resolution of inflammation: the cardinal role of integrins.Kourtzelis I*, Mitroulis I, von Renesse J, Hajishengallis G, Chavakis T*. *Correspondence authorJ Leukoc Biol. 2017 Mar 14. pii: jlb.3MR0117-024R. doi: 10.1189/jlb.3MR0117-024R. [Epub ahead of print] Review

The dual role of complement in cancer and its implication in anti-tumor therapy. Kourtzelis I*, Rafail S*. *Correspondence author. Ann Transl Med. 2016 Jul;4(14):265. doi: 10.21037/atm.2016.06.26. Review.

Leukocyte integrins: role in leukocyte recruitment and as therapeutic targets in inflammatory disease. Mitroulis I*, Alexaki VI*, Kourtzelis I, Ziogas A, Hajishengallis G, Chavakis T. *Equal contribution. Pharmacol Ther. 2015 Mar;147:123-35