Dr Jason Boland

MB, BChir, MA, MRCP, FRCP, DTM&H, FHEA, PhD

Senior Clinical Lecturer and Honorary Consultant in Palliative Medicine

Role at Hull York Medical School

I am a senior clinical lecturer and honorary consultant in palliative medicine at Hull York Medical School, with my clinical work in North-East Lincolnshire, working with the hospice, hospital and community teams. At HYMS I have both research and education roles.

I am chair of the mitigating circumstances committee, senior student advisor, mentor to year 3, 4 and 5 students, academic lead for palliative care (attained new HEE funding for increased delivery of specialist palliative care teaching), curriculum advisor and co-lead for the metabolic block. I was lead for the cancer block and have been central to cancer and general palliative care becoming a longitudinal theme across phase 2.

I supervise MD and PhD students, publish and lecture widely and am developing palliative medicine research in NE Lincolnshire.

Biography

Jason Boland is a senior clinical lecturer and honorary consultant in palliative medicine at Hull & York Medical School and North East Lincolnshire. He qualified in medicine from the University of Cambridge in 1999, with an MA in neuroscience. He completed his higher specialist training in palliative medicine in Sheffield, where for his PhD he performed a systematic analysis of the in vitro effect of opioids on adaptive and innate immune function. He is collaborating on a European trial to evaluate the effect of opioids on immune and endocrine function in opioid naive patients randomised to receive weak or strong opioids.

His interests include understanding the molecular actions of opioids and how to maximise their efficacy while minimising toxicity as well as development and improvement of the delivery of palliative care. He is currently researching the effect of opioids on immune, endocrine, gastrointestinal and cognitive function, and is also involved in non-malignant lung disease research. He lectures nationally and internationally on these topics. He is on the sub-committee of an international pharmacovigilance audit which is assessing the benefits and toxicity of Haloperidol for Nausea. He is developing palliative care research in NE Lincolnshire where he is currently the PI on 2 portfolio studies.

He is the elected Chair of the Science Committee of the Association for Palliative Medicine (UK and Ireland) as well as being on their Executive Committee. He is on the organising committee for the palliative care congress and Association for Palliative Medicine conference; and leads on organising their research study days. He is an NIHR Dissemination Centre panel of expertcommentator. He is on the gastrointestinal subgroup and Early Stage and Acute Toxicities Subgroup of the NCRI Supportive & Palliative Care CSG, and on the Steering Group for NIHR Themed Review on End of Life Care. He is an associate editor for BMJ Supportive and Palliative Care and is on the editorial board for the journal Palliative Medicine and for the Palliative Care Formulary. He is the editor for a evidence update blog for the BMJ Supportive & Palliative Care Journal http://blogs.bmj.com/spcare/category/short-cuts/He regularly delivers undergraduate and postgraduate teaching, including SSCs/SSIPs, and is involved in reviewing and reshaping the palliative medicine curriculum in HYMS. He is the academic lead for palliative medicine and led the cancer block. He recently won the Postgraduates' Choice Award for the University of Hull’s Student-Led Teaching Awards: http://hullstudent.com/news/article/student-led-teaching-awards-winners and was a finalist in the HYMS 2016 phase2/3 awards.

Research

Primary supervisor for UoH PhD student - assessing prescribing in patients with dementia in nursing homes.Secondary supervisor for UoH PhD student - assessing apathy in Huntington’s disease. Primary supervisor for UoH research MD student developing a tool for the diagnosis of cluster headachesThesis advisory panel Chair for 1 PhD student, 1 MSc student and TAP member for another PhD student

I have set up and am developing NE Lincolnshire as a palliative medicine research site:

  • I've been awarded £22,482 a year over the past 2 years by the NIHR clinical research network for a research nurse
  • PI for Improving Rehabilitation in Palliative care using Goal attainmentScaling (GAS)  - portfolio study
  • PI for Improving the Management of pain from advanced cancer in the Community (IMPACCT) - portfolio study
  • PI for The Prognosis in Palliative care Study (PiPS2) - portfolio study
  • PI for Self-Management of Analgesia and Related Treatments at the End of life portfolio study (pilot site)
  • PI for carers needs study - portfolio study
  • PI on CRN portfolio study to assess the impact of opioid induced constipation on patients - portfolio study

In Hull, I am PI for The Palliative Radiotherapy And Inflammation Study (PRAIS)  and Validation of a palliative needs assessment tool in ILD (NA-ILD) study - portfolio studies.

I am currently collaborating with Prof Fallon in Edinburgh, who is leading on a study assessing the immune and endocrine function in patients with cancer commencing opioids.I am collaborating with Prof Johnson and colleagues in London and Manchester to develop a tool to assess needs in patients with interstitial lung disease. CRUK Marie Curie £117,462.CI on a qualitative study to explore palliative care nurses perceptions of the multiprofessional education of medical students.CI on a qualitative study using reflective essays to explore medical students perceptions of palliative care patients.Developing translational immunology studies to assess the pre-clinical impact of early palliative care in NSCLC.NIHR Comprehensive Clinical Research Network research Clinical Lead for NE Lincolnshire Community. I have been awarded £19,958 by Macmillan via Hull Churches Home from Hospital Service to evaluate and develop a training and support package for their Families together projectI am the CI on 2 qualitative education projects, including an international one exploring palliative care nurses perceptions of the multiprofessional education of medical students.

Co-applicant for Wolfson Palliative care centre bid, £500,000 - 2016

Co-applicant for Yorkshire Cancer Research Endowment grant, £5.2 million, 2017

Teaching
  1. Membership
    1. Board of Studies
    2. Phase II & III Curriculum Management Group
  2. Academic lead for palliative care:
    1. Attained new HEE funding for increased delivery of specialist palliative care  across HYMS
    2. After completing a full mapping process of palliative care undergraduate teaching in HYMS we have developed general palliative care as a parallel theme across all medical and surgical attachments.
    3. Developing learning objectives for this theme
    4. Developing a specialist palliative care attachment across HYMS
    5. Curriculum review and implementation for general and specialist palliative care
  3. Metabolic medicine block lead:
    1. Coordination of block, including exam question writing
    2. Exam question selection
    3. Question writing
    4. Exam marking and moderating
  4. I was lead for the cancer block, developing Blackboard, on-lineresources and a HYMS wide radiotherapy study day, and have been central to cancer and general palliative care becoming a longitudinal theme across phase 2.

 

  1. Undergraduate exams:
    1. Block 17 Exam question writing and reviewing - MCQs, MEQs and EMQs.
    2. Writing e-learning exam questions
    3. Phase 1, 2 and 3 Standard setting
    4. Phase 1, 2 and 3 exam marking
    5. Phase  1, 2 and 3  examination paper reviews
    6. Phase 1, 2 and 3 Board of Examiners meeting
  2. Communication masterclasses:
    1. Delivered and led phase II and III communication masterclasses
    2. Built up a base of tutors on the south bank, now developing other areas
  3. Undergraduate lectures:
    1. Plenary lectures, phase 1 block 13 – palliative care service provision
    2. Plenary lectures, phase 2 - Pain PPT
    3. Phase 1 spiritual issues in end of life care – single site interactive lecture
    4. HYMS year 4 critical appraisal revision sessions
  4. Undergraduate cancer block 17 teaching phase 2:
    1. Development of the NE Lincolnshire undergraduate palliative medicine teaching
    2. Delivery of case review sessions to the medical students
    3. Delivery of lectures to the medical students
    4. Increased students time in hospice
    5. DNACPR and breaking bad news teaching
  5. HYMS Elective student (part placement in Grimsby)
  6. Mentor for 8 phase 2 students.
  7. SSC/SSIP:
    1. Developed and delivered a phase 1 SSC to introduce students to palliative medicine and its principals
    2. Developed and led on a phase 2 SSC in Grimsby (4 students, 3 times a year) to further students clinical understanding of palliative medicine
    3. Setup, led, developed and delivered a phase 1 palliative medicine SSIP
    4. Setup, led, developed and delivered a phase 2 palliative medicine SSIP
  8. Non-HYMS:
    1. Deliver metabolic derangement and clinical scenarios in cachexia lectures on post-graduate MSc
    2. Question writing and marking for MSc in nutrition exam
    3. Palliative care lectures to MSc in Translational Oncology
    4. Question writing for MSc in Translational Oncology exam
Publications

Boland JW, Johnson MJ, Ferreira DH, Berry DJ. In silico (computed) modelling of doses and dosing regimens associated with morphine levels above international legal driving limits. Palliative Medicine 2018. In press

Boland JW, Pockley AG. Influence of opioids on immune function in patients with cancer pain: from bench to bedside. British Journal of Pharmacology. In press Full text

Ferreira DH, Boland JW, Phillips JL, Lam L, Currow DC. The impact of therapeutic opioid agonists on driving-related psychomotor skills assessed by a driving simulator or an on-road driving task: A systematic review. Palliat Med 2018. 32(4):786-803. Full text

Star A, Boland JW. Updates in palliative care – recent advancements in the pharmacological management of symptoms. Clin Med 2018 18:11-16 Full text

Wood H, Dickman A, Star A, Boland JW. Updates in palliative care – overview and recent advancements in the pharmacological management of cancer pain. Clin Med 2018 18:17-22 Full text

Gadoud A, Lu W, Lane S, Strano-Paul S, Boland JW. A pilot study of interprofessional palliative care education of medical students in the UK and USA. BMJ Supportive & Palliative Care 2018. 8(1):67-72. Full text

 Johnson MJ, Jamali A, Ross J, Fairhurst C, Boland J, Reigada C, Hart SP, Grande G, Currow DC, Wells AU, Bajwah S, Papadopoulos T, Bland JM, Yorke J.Psychometric validation of the needs assessment tool: progressive disease in interstitial lung disease. Thorax. In press. Full text

Digges M, Hussein A, Wilcock A, Crawford GB, Boland JW, Agar MR, Sinnarajah A, Currow DC, Johnson MJ. Pharmacovigilance in Hospice/Palliative Care: Net Effect of Haloperidol for Nausea or Vomiting. J Palliat Med 2018. 21(1):37-43

Boland JW, Boland EG. Pharmacological therapies for opioid-induced constipation in adults with cancer. BMJ. 2017 Aug 2;358:j3313 Full text

Boland JW, Allgar V, Boland EG, Oviasu O, Agar M, Currow DC,  Johnson MJ.  Effect of opioids and benzodiazepines on clinical outcomes in patients receiving palliative care; an exploratory analysis. Journal of Palliative Medicine 2017. 20(11):1274-1279. Full text

Fearnley R, Boland JW. Communication and support from health care professionals to families, with dependent children, following the diagnosis of parental life-limiting illness: A systematic review. Palliative Medicine;2017 Mar;31(3):212-222 Full Text

Reigada C, Papadopoulos A, Boland J, Yorke J, Ross J, Currow DC, Bajwah S, Grande G, Wells A, Johnson MJ. Implementation of the Needs Assessment Tool for Interstitial Lung Disease Patients (NAT:ILD): Facilitators and Barriers. Thorax 2017.  72(11):1049-1051.

Boland JW, Dikomitis L, Gadoud A. Medical students writing on death, dying and palliative care: A qualitative analysis of reflective essays. BMJ SPC. 2016 Dec;6(4):486-492 Full text 

Obita GP, Boland EG, Currow DC, Johnson MJ, Boland JW. Somatostatin analogues compared to placebo and other pharmacological agents in the management of symptoms of inoperable malignant bowel obstruction: a systematic review. JPSM. 2016;52(6):901-919 Full text

Boland JW, Bennett MI. Opioids do not influence metastasis in experimental animal cancer models. Pain 2016;157(5):1173

Facey C, Brooks D, Boland JW. Assessment of the appropriateness of naloxone administration to patients receiving long-term opioid therapy. Hospital Practice 2016;44(2):86-91 Full text 

Boland JW, Reigada C, Yorke J, Hart SP, Bajwah S, Ross J, Wells A, Papadopoulos A, Currow D, Grande G, Macleod U, Johnson M. The adaptation, face and content validation of a Needs Assessment Tool: Progressive Disease for people with interstitial lung disease (NAT:PD-ILD). Journal of Palliative Medicine 2016 (5):549-55. Full text 

Boland JW, Ziegler L, Boland EG, McDermid K, Bennett MI. Is regular systemic opioid analgesia associated with shorter survival in adult patients with cancer? A systematic literature review. Pain 2015 Nov;156(11):2152-63. Full text

Ahmedzai SH, Boland JW. Constipation: opioid antagonists in people prescribed opioids. BMJ Clin Evid 2015. Full text

Sloot S, Boland J, Ezaydi Y, Gethin A, Green T, Chopra L, Engels Y, Verhagen S, Vissers K, Snowden J, Ahmedzai SH. Side effects of analgesia may significantly reduce quality of life in symptomatic multiple myeloma: a cross-sectional pilot study. Supportive Care in Cancer 2015 Mar;23(3):671-8. Full text

Boland JW, McWilliams K, Ahmedzai SH, Pockley AG. Effects of opioids on immunological parameters that are relevant to anti-tumour immune potential in patients with cancer: a systematic literature review. British Journal of Cancer 2014 Aug;111(5):866-73. Full text

Boland JW, Currow D, Wilcock A, Tieman J, Hussain J, Pitsillides C, Abernethy A, Johnson M. A systematic review of strategies used to increase recruitment of people with cancer or organ failure into clinical trials: implications for palliative care research. JPSM 2014. 49 (4), 762-772. Full text

Boland JW, Foulds G, Ahmedzai SH, Pockley AG. A systematic analysis of the in vitro effects of opioids on innate and adaptive immune function. BMJ Supportive & Palliative Care 2014 Dec;4(4):357-67. Full text

Kyeremateng S, Boland JW. Aprepitant for the Management of Refractory Emesis in a Patient with a Small Bowel Carcinoid Tumor. Journal of Pain and Palliative Care Pharmacotherapy 2014 Jun;28(2):135-7. Full text

Boland EG, Boland JW, Ezaydi Y, Greenfield DM, Ahmedzai SH, Snowden JA. Holistic needs assessment in advanced, intensively-treated multiple myeloma patients. Supportive Care in Cancer 2014 Oct;22(10):2615-20. Full text

Taubert M, Watts G, Boland J, Radbruch, L. Palliative Social Media. BMJ Supportive & Palliative Care 2014; 4(1):13-18. Full text

Boland J, Owen J, Ainscough A, Mahdi H. Developing a Service for Patients with Very Severe Chronic Obstructive Pulmonary Disease (COPD) within resources. BMJ SPC 2014;4:196-201. Full text

Boland J, Rennick A. Unusual aetiology of malignant spinal cord compression. BMJ Supportive & Palliative Care 2013;3:200–202.

Boland J, Boland E, Brooks D. Importance of the correct diagnosis of opioid-induced respiratory depression in adult cancer patients and titration of naloxone. Clinical Medicine 2013, Vol 13, No 2: 149–51.

Boland J, Johnson M. Non-malignant editorial: End of life care for non-cancer patients. BMJ SPC 2013;3:2–3.

Boland J, Brooks D. Topical application of a beclometasone aerosol inhaler for the treatment of peristomal inflammation; a case report.2012 Palliative Medicine 26 (8) 1055-1056

Boland J, Cachia E, Portenoy RK, Ahmedzai SH. Pain in respiratory disease - mechanisms and management. In supportive Care in Respiratory Disease, Second Edition. Edited by Sam H. Ahmedzai, David R. Baldwin, and David C. Currow. OUP 2012.

Cachia E, Boland J, Ahmedzai SH. Pain assessment in respiratory disease. In supportive Care in Respiratory Disease, Second Edition. Edited by Sam H. Ahmedzai, David R. Baldwin, and David C. Currow. OUP 2012.

Boland J. How to write an effective application for a research grant. European Journal of Palliative Care, 2010; 17(4), 194-6

Ahmedzai SH, Boland J. Constipation in people prescribed opioids. BMJ Clinical Evidence revised and updated 2010.http://www.clinicalevidence.com/ceweb/conditions/bly/2407/2407.jsp

Boland J, Ahmedzai SH. A novel targeted therapy for opioid-induced bowel dysfunction: methylnaltrexone. European Journal of Palliative Care 2008; Suppl Dec.

Ahmedzai SH, Boland J. Constipation in people prescribed opioids. BMJ Clinical Evidence 2007.http://www.clinicalevidence.bmj.com/x/systematic-review/2407/archive/06/2007.html

Ahmedzai SH, Boland J. Opioids for chronic pain: molecular and genomic basis of actions and adverse effects Curr Opin Support Palliat Care 2007, 1:117–125

Ahmedzai SH, Boland J. The total challenge of cancer pain in supportive and palliative care. Curr Opin Support Palliat Care 2007, 1:3–5

BMJ Supportive & Palliative Care evidence updates (shortcuts):

 

  • BMJ Supportive & Palliative Care 2016;6:415-416
  • BMJ Supportive & Palliative Care 2016;6:254-5
  • BMJ Supportive & Palliative Care 2016;6:149-50
  • BMJ Supportive & Palliative Care 2015;5:221-222
  • BMJ Supportive & Palliative Care 2015;5:127-128
  • BMJ Supportive & Palliative Care 2015;5:10-11
  • BMJ Supportive & Palliative Care 2014;4:329-330
  • BMJ Supportive & Palliative Care 2014;4:224-225
  • BMJ Supportive & Palliative Care 2014;4:128-129
  • BMJ Supportive & Palliative Care 2014;4:11-12
  • BMJ Supportive & Palliative Care 2013;3:381-382
  • BMJ Supportive & Palliative Care 2013;3:296-297
  • BMJ Supportive & Palliative Care 2013;3:141-143
  • BMJ Supportive & Palliative Care 2013;3:34-36
  • BMJ Supportive & Palliative Care 2012;2-310-1
  • BMJ Supportive & Palliative Care 2012;2-216-7
  • BMJ Supportive & Palliative Care 2012;2:101-102
  • BMJ Supportive & Palliative Care 2012;2:15–16
  • BMJ Supportive & Palliative Care 2011;1:290
  • BMJ Supportive & Palliative Care 2011;1:134
  • BMJ Supportive & Palliative Care 2011;1:12
Collaborations

Professor Pål Klepstad, Norwegian University of Science and Technology (NTNU), Trondheim, Norway The Palliative Radiotherapy And Inflammation Study – PRAIS

Professor Fallon, University of Edinburgh: effect of opioids on immune and endocrine function

Professor Bennett, University of Leeds:

  1. SMARTE study;
  2. effect of opioids on survival.

Professor Ahmedzai, University of Sheffield:

translational immunological studies to assess the pre-clinical impact of early palliative care in NSCLC

Professor Johnson (Hull) and Prof Wells and Dr’s Ross and Bajwah in London and Prof’s Grande and Yorke in Manchester to develop a tool to assess needs in patients with interstitial lung disease

Dr Rachel Fearnley, Independent Researcher:

  1. Hull Churches Home from Hospital Service Families Together Project;
  2. Communication and support from health care professionals to families, with dependent children, following the diagnosis of parental life-limiting illness: A systematic review.

Professor Currow, Flinders University:  

  1. Somatostatin analogues compared to placebo and other pharmacological agents in the management of symptoms of inoperable malignant bowel obstruction: a systematic review;
  2. effect of opioids, benzodiazepines and anti-cholinergic load on clinical outcomes in patients receiving palliative care