Dr Simon Hart

BSc(Hons) MBChB(Hons) PhD FRCPE

Senior Lecturer in Respiratory Medicine

Biography

Senior Lecturer in Respiratory Medicine at Hull York Medical School and the University of Hull.

Graduated from Edinburgh University and trained in respiratory and general (internal) medicine in south-east Scotland. PhD on neutrophil and macrophage biology and cell surface alterations associated with apoptosis (programmed cell death) in the MRC Centre for Inflammation Research. Awarded an MRC Clinician Scientist fellowship.

Honorary Consultant in Respiratory Medicine at Castle Hill Hospital. Lead clinician for the Hull interstitial lung disease service. Participates in the acute general medicine rota at Hull Royal Infirmary.

Research interests include the pathogenesis of idiopathic pulmonary fibrosis and other interstitial lung diseases, immunology of pulmonary fibrosis and sarcoidosis.

Research

The respiratory research group is based in the Daisy Clinical Research and Teaching Building (2nd floor), Castle Hill HospitalWe use a translational biology "bench to bedside" approach to address research questions in pulmonary fibrosis and sarcoidosis. 

Idiopathic pulmonary fibrosisIdiopathic pulmonary fibrosis (IPF) is a progressive scarring disease of the lungs that affects 15,000 people in the UK. We believe that development of effective therapies in the future will depend on a better understanding of what initiates and perpetuates lung scarring.

  • We have discovered abnormalities of platelet function in patients with IPF. We are studying how the pulmonary vascular endothelium responds to injury and how these responses contribute to pulmonary fibrosis by promoting retention and activation of platelets in the lungs.
  • Pulmonary fibrosis commonly complicates rheumatic diseases, and a related research theme is exploring the relationship between autoimmunity and lung inflammation and fibrosis.
  • We are developing novel imaging techniques in pulmonary fibrosis, both in the lab (in collaboration with Hull University Dept. of chemistry) and in the clinic.
  • We have an ongoing interest in assessing and treating symptoms in pulmonary fibrosis, particularly breathlessness and cough.

SarcoidosisSarcoidosis is a chronic inflammatory disease of unknown cause, characterised by hyper-activation of immune cells. Whilst some cases remit spontaneously, there is no curative treatment.

  • We are studying immune responses in the blood and lung tissue of patients with sarcoidosis to help understand how the disease is initiated and driven. We are particularly interested in how abnormal function of regulatory (inhibitory) receptors on blood monocytes leads to an overactive immune system in sarcoidosis.

Thanks to our current funders -

SarcoidosisUK

British Lung Foundation

Sir Jules Thorn Charitable Trust

Foundation for Sarcoidosis Research

Boehringer Ingelheim

Teaching

Co-lead for academic foundation program at HYMS

Year 3 clinical tutor

Former chair, HYMS Academic Progress Committee

Former block lead for year 3 cardiovascular/respiratory medicine/dermatology

Publications
Collaborations

Immunology of sarcoidoisis (Prof P Kaye, York; Prof M Coles, Oxford)

Computational modelling of inflammation (Prof J Timmis, York)

Palliation of chronic breathlessness (Prof M Johnson, HYMS)

Platelet biology in pulmonary fibrosis (Prof K Naseem, Leeds)

PET imaging with novel tracers (Prof S Archibald, Dr C Cawthorne, Hull)

Novel lung imaging in patients with ILD (Prof J Wild, Sheffield)