Professor Thozhukat Sathyapalan

MBBS, MD, FRCP, FACP, FHEA

Chair in Academic Endocrinology, Diabetes and Metabolism / Honorary Consultant Physician

Role at Hull York Medical School

Thozhukat Sathyapalan (Sathya) is the Chair in Academic Diabetes, Endocrinology and Metabolism in Hull York Medical School, University of Hull and Honorary Consultant Endocrinologist at Hull and East Yorkshire Hospitals NHS Trust, UK. He obtained his undergraduate degree in Medicine from University of Kerala, India in 1996 and his MD (General Medicine) from JIPMER, India. He subsequently did his clinical training in Diabetes and Endocrinology as a Specialist Registrar in Yorkshire Deanery. Sathya was a Clinical Research Fellow in University of Hull and obtained his MD (Diabetes and Endocrinology) in 2009. He was appointed as Senior Lecturer in Hull York Medical School in October 2009, Reader in 2012 and was made Chair in Academic Endocrinology and Metabolism in 2016.

Biography
  • MBBS, Trivandrum Medical College, India 1990-1996
  • MD (General Medicine), JIPMER, India 1997-2000
  • Postgraduate Clinical Training (Grampian University Hospitals and Yorkshire Deanery) 2001-2009
  • Clinical Research Fellow, University of Hull 2006-2008
  • Senior Lecturer, Hull York Medical School 2009-2012
  • Reader, Academic Diabetes, Endocrinology and Metabolism 2013-2016
  • Chair, Academic Diabetes, Endocrinology and Metabolism 2016 -
Research

His main area of interest is on modulation of cardiovascular risk through pharmacological and nutritional interventions in insulin resistant states such as obesity, polycystic ovary syndrome (PCOS) and type 2 diabetes mellitus.  He is interested in traditional as well as novel risk factors, specifically endocrine disruptors.

Teaching

Postgraduate (clinical)

  • Organise and lead the Continuing Medical Education programme for endocrine trainees and Consultants in Diabetes and Endocrinology for Health Education Yorkshire and the Humber. RCP-accredited. Delivered by national and international speakers.
  • Educational and Clinical Supervisor for Foundation year trainees, Core Medical trainees and Specialty Trainees in Endocrinology and diabetes

Undergraduate

  • Delivering plenary lectures for HYMS students
  • Phase II Student Selected Components (SSCs) on ‘patient pathway through research’
  • Critically appraised topic (CAT) assessment for Phase II students
  • Thyroid teaching clinics and diabetes teaching clinics for HYMS Year 4 students
  • Multi-disciplinary clinical teaching for Year 3 students: type 1 and type 2 diabetes, dedicated sessions with diabetes specialist nurses, podiatrists, and dieticians
  • OSLER and OSCE examiner for HYMS Year 4 and 5 medical students
Publications
  • Sathyapalan T, Javed Z, Rigby AS, Kilpatrick ES, Atkin SL. Soy Protein Improves Cardiovascular Risk in Subclinical Hypothyroidism: A Randomized Double-Blinded Crossover Study. J Endocr Soc 2017; 1:423-430
  • Sathyapalan T, Al-Qaissi A, Kilpatrick ES, Dargham SR, Atkin SL. Anti-Mullerian hormone measurement for the diagnosis of polycystic ovary syndrome. Clin Endocrinol (Oxf) 2017;
  • Sathyapalan T, Aye M, Rigby AS, Fraser WD, Kilpatrick ES, Atkin SL. Effect of soy on bone turn-over markers in men with type 2 diabetes and hypogonadism - a randomised controlled study. Sci Rep 2017; 7:15366
  • O'Doherty AF, Jones HS, Sathyapalan T, Ingle L, Carroll S. The Effects of Acute Interval Exercise and Strawberry Intake on Postprandial Lipemia. Med Sci Sports Exerc 2017; 49:2315-2323
  • Sathyapalan T, Coady AM, Kilpatrick ES, Atkin SL. The effect of atorvastatin on pancreatic beta cell requirement in women with polycystic ovary syndrome. Endocr Connect 2017; 6:811-816
  • Gonzalez S, Windram JD, Sathyapalan T, Javed Z, Clark AL, Atkin SL. Effects of human recombinant growth hormone on exercise capacity, cardiac structure, and cardiac function in patients with adult-onset growth hormone deficiency. J Int Med Res 2017; 45:1708-1719
  • Sathyapalan T, Dickerson EH, Maguiness SM, Robinson J, Dakroury YHZ, Atkin SL. Androstenedione and testosterone levels correlate with in vitro fertilization rates in insulin-resistant women. BMJ Open Diabetes Res Care 2017; 5:e000387
  • Dawson AJ, Kilpatrick ES, Coady AM, Elshewehy AMM, Dakroury Y, Ahmed L, Atkin SL, Sathyapalan T. Endocannabinoid receptor blockade reduces alanine aminotransferase in polycystic ovary syndrome independent of weight loss. BMC Endocr Disord 2017; 17:41
  • Wells L, Hardie L, Williams C, White K, Liu Y, De Santis B, Debegnach F, Moretti G, Greetham S, Brera C, Papageorgiou M, Thatcher NJ, Rigby A, Atkin SL, Sathyapalan T. Deoxynivalenol Biomarkers in the Urine of UK Vegetarians. Toxins (Basel) 2017; 9
  • Sathyapalan T, Al-Qaissi A, Kilpatrick ES, Dargham SR, Adaway J, Keevil B, Atkin SL. Salivary testosterone measurement in women with and without polycystic ovary syndrome. Sci Rep 2017; 7:3589
  • Cho LW, Sathyapalan T, Kilpatrick ES, Keevil BG, Miller AG, Coady AM, Ahmed L, Atkin SL. Androsterone glucuronide to dehydroepiandrosterone sulphate ratio is discriminatory for obese Caucasian women with polycystic ovary syndrome. BMC Endocr Disord 2017; 17:26
  • Sathyapalan T, Rigby AS, Bhasin S, Thatcher NJ, Kilpatrick ES, Atkin SL. Effect of Soy in Men With Type 2 Diabetes Mellitus and Subclinical Hypogonadism: A Randomized Controlled Study. J Clin Endocrinol Metab 2017; 102:425-433
  • Sathyapalan T, Javed Z, Kilpatrick ES, Coady AM, Atkin SL. Endocannabinoid receptor blockade increases vascular endothelial growth factor and inflammatory markers in obese women with polycystic ovary syndrome. Clin Endocrinol (Oxf) 2017; 86:384-387
  • Sathyapalan T, Aye M, Rigby AS, Fraser WD, Thatcher NJ, Kilpatrick ES, Atkin SL. Soy Reduces Bone Turnover Markers in Women During Early Menopause: A Randomized Controlled Trial. J Bone Miner Res 2017; 32:157-164
  • Abiola D, Sathyapalan T, Hepburn D 2016 Management of type 1 and type 2 diabetes requiring insulin. Prescriber 27.09
  • Sathyapalan T, Javed Z, Kilpatrick ES, Coady AM, Atkin SL 2016 Endocannabinoid receptor blockade increases vascular endothelial growth factor and inflammatory markers in obese women with polycystic ovary syndrome. Clin Endocrinol (Oxf)
  • Javed Z, Sathyapalan T 2016 Levothyroxine treatment of mild subclinical hypothyroidism: a review of potential risks and benefits. Ther Adv Endocrinol Metab 7:12-23
  • Simintiras CA, Frohlich T, Sathyapalan T, Arnold GJ, Ulbrich SE, Leese HJ, Sturmey RG. Modelling oviduct fluid formation in vitro. Reproduction 2016.O'Doherty AF, Sathyapalan T, Rigby AS, Ingle L, Carroll S. The repeatability of the abbreviated (4-h) oral fat tolerance test and influence of prior acute aerobic exercise. Eur J Nutr 2016.            
  • Greetham S, Goodwin S, Wells L, Whitham C, Jones H, Rigby A, Sathyapalan T, Reid M, Atkin S 2016 Pilot Investigation of a Virtual Gastric Band Hypnotherapy Intervention. Int J Clin Exp Hypn 64:419-433
  • Sathyapalan T, Thatcher NJ, Hammersley R, Rigby AS, Courts FL, Pechlivanis A, Gooderham NJ, Holmes E, le Roux CW, Atkin SL 2015 Aspartame sensitivity? A double blind randomised crossover study. PLoS One 10:e0116212
  • Sathyapalan T, David R, Gooderham NJ, Atkin SL 2015 Increased expression of circulating miRNA-93 in women with polycystic ovary syndrome may represent a novel, non-invasive biomarker for diagnosis. Sci Rep 5:16890
  • Sathyapalan T, Atkin SL, Kilpatrick ES 2015 LDL cholesterol variability in patients with Type 2 diabetes taking atorvastatin and simvastatin: a comparison of two formulae for LDL-C estimation. Ann Clin Biochem 52:180-182
  • Mellor DD, Sathyapalan T, Kilpatrick ES, Atkin SL 2015 Diabetes and chocolate: friend or foe? J Agric Food Chem 63:9910-9918
  • Javed Z, Qamar U, Sathyapalan T 2015 The role of kisspeptin signalling in the hypothalamic-pituitary-gonadal axis--current perspective. Endokrynol Pol 66:534-547
  • Javed Z, Qamar U, Sathyapalan T 2015 Pituitary and/or hypothalamic dysfunction following moderate to severe traumatic brain injury: Current perspectives. Indian J Endocrinol Metab 19:753-763
  • George A, Bhatia RT, Buchanan GL, Whiteside A, Moisey RS, Beer SF, Chattopadhyay S, Sathyapalan T, John J 2015 Impaired Glucose Tolerance or Newly Diagnosed Diabetes Mellitus Diagnosed during Admission Adversely Affects Prognosis after Myocardial Infarction: An Observational Study. PLoS One 10:e0142045
  • Dawson AJ, Sathyapalan T, Smithson JA, Vince RV, Coady AM, Ajjan R, Kilpatrick ES, Atkin SL 2014 A comparison of cardiovascular risk indices in patients with polycystic ovary syndrome with and without coexisting nonalcoholic fatty liver disease. Clin Endocrinol (Oxf) 80:843-849
  • Dawson AJ, Sathyapalan T, Sedman P, Ajjan R, Kilpatrick ES, Atkin SL 2014 Insulin resistance and cardiovascular risk marker evaluation in morbid obesity 12 months after bariatric surgery compared to weight-matched controls. Obes Surg 24:349-358
  • Sathyapalan T, Shepherd J, Atkin SL, Kilpatrick ES 2013 The effect of atorvastatin and simvastatin on vitamin D, oxidative stress and inflammatory marker concentrations in patients with type 2 diabetes: a crossover study. Diabetes Obes Metab 15:767-769
  • Kamalanathan S, Sahoo JP, Sathyapalan T 2013 Pregnancy in polycystic ovary syndrome. Indian J Endocrinol Metab 17:37-43
  • Dawson AJ, Sathyapalan T, Atkin SL, Kilpatrick ES 2013 Biological variation of cardiovascular risk factors in patients with diabetes. Diabet Med 30:1172-1180
  • Shor D, Sathyapalan T, Atkin SL, Thatcher NJ 2012 Does equol production determine soy endocrine effects? Eur J Nutr 51:389-398
  • Sathyapalan T, Smith KA, Coady AM, Kilpatrick ES, Atkin SL 2012 Atorvastatin therapy decreases androstenedione and dehydroepiandrosterone sulphate concentrations in patients with polycystic ovary syndrome: randomized controlled study. Ann Clin Biochem 49:80-85
  • Sathyapalan T, Shepherd J, Coady AM, Kilpatrick ES, Atkin SL 2012 Atorvastatin reduces malondialdehyde concentrations in patients with polycystic ovary syndrome. J Clin Endocrinol Metab 97:3951-3955
  • Sathyapalan T, Dixit S 2012 Radiotherapy-induced hypopituitarism: a review. Expert Rev Anticancer Ther 12:669-683
  • Sathyapalan T, Atkin SL 2012 Recent advances in cardiovascular aspects of polycystic ovary syndrome. Eur J Endocrinol 166:575-583
  • Kahal H, Aye M, Rigby AS, Sathyapalan T, England RJ, Atkin SL 2012 The effect of parathyroidectomy on neuropsychological symptoms and biochemical parameters in patients with asymptomatic primary hyperparathyroidism. Clin Endocrinol (Oxf) 76:196-200
  • Wakil A, Sathyapalan T, Atkin SL 2011 Pituitary hypophysitis and gulf war syndrome: a case series and hypothesis. Clin Endocrinol (Oxf) 75:272-274
  • Thong KY, Jose B, Sukumar N, Cull ML, Mills AP, Sathyapalan T, Shafiq W, Rigby AS, Walton C, Ryder RE, Contributors ANEA 2011 Safety, efficacy and tolerability of exenatide in combination with insulin in the Association of British Clinical Diabetologists nationwide exenatide audit*. Diabetes Obes Metab 13:703-710
  • Thong KY, Jose B, Blann AD, Cull ML, Mills AP, Sathyapalan T, Walton C, Ryder RE 2011 Response at 3 months to insulin dose decisions made at exenatide initiation in the Association of British Clinical Diabetologists (ABCD) nationwide exenatide audit. Diabetes Res Clin Pract 93:e87-91
  • Sathyapalan T, Manuchehri AM, Thatcher NJ, Rigby AS, Chapman T, Kilpatrick ES, Atkin SL 2011 The effect of soy phytoestrogen supplementation on thyroid status and cardiovascular risk markers in patients with subclinical hypothyroidism: a randomized, double-blind, crossover study. J Clin Endocrinol Metab 96:1442-1449
  • Sathyapalan T, Aye MM, Atkin SL 2011 Postural hypotension. BMJ 342:d3128
  • Sathyapalan T, Atkin SL 2011 Is there a role for immune and anti-in-flammatory therapy in type 2 diabetes? Minerva Endocrinol 36:147-156
  • Kahal H, Atkin SL, Sathyapalan T 2011 Pharmacological treatment of obesity in patients with polycystic ovary syndrome. J Obes 2011:402052
  • Dickerson EH, Sathyapalan T, Knight R, Maguiness SM, Killick SR, Robinson J, Atkin SL 2011 Endocrine disruptor & nutritional effects of heavy metals in ovarian hyperstimulation. J Assist Reprod Genet 28:1223-1228
  • Dawson AJ, Mellor DD, Sathyapalan T, Kilpatrick ES, Atkin SL 2011 Metformin may maintain weight loss in obese patients with dysglycaemia initially treated with rimonabant. Diabet Med 28:124-125
  • Sathyapalan T, Shepherd J, Arnett C, Coady AM, Kilpatrick ES, Atkin SL 2010 Atorvastatin increases 25-hydroxy vitamin D concentrations in patients with polycystic ovary syndrome. Clin Chem 56:1696-1700
  • Sathyapalan T, Mellor D, Atkin SL 2010 Obesity and gestational diabetes. Semin Fetal Neonatal Med 15:89-93
  • Sathyapalan T, Manuchehri AM, Rigby AS, Atkin SL 2010 Subclinical hypothyroidism is associated with reduced all-cause mortality in patients with type 2 diabetes. Diabetes Care 33:e37
  • Sathyapalan T, Kilpatrick ES, Coady AM, Atkin SL 2010 Atorvastatin pretreatment augments the effect of metformin in patients with polycystic ovary syndrome (PCOS). Clin Endocrinol (Oxf) 72:566-568
  • Sathyapalan T, Cho L, Kilpatrick ES, Le Roux CW, Coady AM, Atkin SL 2010 Effect of rimonabant and metformin on glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1 in obese women with polycystic ovary syndrome. Clin Endocrinol (Oxf) 72:423-425
  • Sathyapalan T, Beckett S, Rigby AS, Mellor DD, Atkin SL 2010 High cocoa polyphenol rich chocolate may reduce the burden of the symptoms in chronic fatigue syndrome. Nutr J 9:55
  • Sathyapalan T, Atkin SL, Kilpatrick ES 2010 Low density lipoprotein-cholesterol variability in patients with type 2 diabetes taking atorvastatin compared to simvastatin: justification for direct measurement? Diabetes Obes Metab 12:540-544
  • Sathyapalan T, Atkin SL, Kilpatrick ES 2010 Disparate effects of atorvastatin compared with simvastatin on C-reactive protein concentrations in patients with type 2 diabetes. Diabetes Care 33:1948-1950
  • Sathyapalan T, Atkin SL 2010 Evidence for statin therapy in polycystic ovary syndrome. Ther Adv Endocrinol Metab 1:15-22
  • Sathyapalan T, Atkin SL 2010 Mediators of inflammation in polycystic ovary syndrome in relation to adiposity. Mediators Inflamm 2010:758656
  • Mellor DD, Sathyapalan T, Kilpatrick ES, Beckett S, Atkin SL 2010 High-cocoa polyphenol-rich chocolate improves HDL cholesterol in Type 2 diabetes patients. Diabet Med 27:1318-1321
  • Sathyapalan T, Kilpatrick ES, Coady AM, Atkin SL 2009 The effect of atorvastatin in patients with polycystic ovary syndrome: a randomized double-blind placebo-controlled study. J Clin Endocrinol Metab 94:103-108
  • Sathyapalan T, Gonzalez S, Atkin SL 2009 Effect of long-term, high-dose estrogen treatment on prolactin levels: a retrospective analysis. Climacteric 12:427-430
  • Sathyapalan T, Cho LW, Kilpatrick ES, Coady AM, Atkin SL 2009 Metformin maintains the weight loss and metabolic benefits following rimonabant treatment in obese women with polycystic ovary syndrome (PCOS). Clin Endocrinol (Oxf) 70:124-128
  • Sathyapalan T, Atkin SL 2009 Investigating hirsutism. BMJ 338:b912
  • Sathyapalan T, Cho LW, Kilpatrick ES, Coady AM, Atkin SL 2008 A comparison between rimonabant and metformin in reducing biochemical hyperandrogenaemia and insulin resistance in patients with polycystic ovary syndrome (PCOS): a randomized open-label parallel study. Clin Endocrinol (Oxf) 69:931-935
  • Sathyapalan T, Atkin SL, Kilpatrick ES 2008 Variability of lipids in patients with Type 2 diabetes taking statin treatment: implications for target setting. Diabet Med 25:909-915
  • Manuchehri AM, Sathyapalan T, Jayagopal V, Kilpatrick ES, Ghatei MA, Bloom SR, Atkin SL 2008 Alterations in thyroid status do not affect plasma peptide YY (PYY) and ghrelin concentrations. Clin Endocrinol (Oxf) 68:836-838
  • Sathyapalan T, Lowry M, Turnbull LW, Rowland-Hill C, Atkin SL 2007 Mechanism of action of octreotide in acromegalic tumours in vivo using dynamic contrast-enhanced magnetic resonance imaging. Pituitary 10:233-236
  • Manuchehri AM, Sathyapalan T, Lowry M, Turnbull LW, Rowland-Hill C, Atkin SL 2007 Effect of dopamine agonists on prolactinomas and normal pituitary assessed by dynamic contrast enhanced magnetic resonance imaging (DCE-MRI). Pituitary 10:261-266
  • Mistry D, Maung KH, Manuchehri AM, Sathyapalan T, Atkin S, England J 2005 Key developments in endocrinology. Practitioner 249:541, 543-547, 549 passim

Book Contributions

  • Qamar U, Atkin SL, Sathyapalan T (2017). Obesity and Polycystic ovary Syndrome (PCOS); Practical guide to obesity medicine. First Edition; Publisher - Elsevier.
  • Aye M, Sathyapalan T (2017) Investigation of hypercalcaemia. Scott-Brown's Otorhinolarnygology and Head and Neck Surgery, Eighth Edition: Publisher - CRC Press
  • Sathyapalan T, Atkin SL (2017) Investigation of Pituitary disease. Scott-Brown's Otorhinolarnygology and Head and Neck Surgery, Eighth Edition: Publisher - CRC Press.Sathyapalan T, Atkin SL (2017) 
  • Evaluation of Hirsutism.  BMJ Point of Care Monograph.Sathyapalan T, Atkin SL (2017) Polycystic ovary syndrome. Tarascon Adult Endocrinology Pocketbook.
  • Sathyapalan T, Wakil A, Atkin SL (2011).  Update on the Management of the Surgical Patient with Diabetes.  In “Recent Advances in Surgery 34” (Ed Irving Taylor and Colin D Johnson).  The Royal Society of Medicine Press, London.
  • Sathyapalan T, Atkin SL (2008). Insulin Resistance and Polycystic Ovary Syndrome. In “Recent Advances in Obstetrics and Gynaecology 24” (Ed. W Ledger and W Dunlop).  The Royal Society of Medicine Press, London, pp 259-280
External roles

Other examining roles

  • External examiner for PhD/MD students
  • Royal Colleges of Physicians membership exam: examiner since 2012s
  • External examiner for Diabetes MSc, PGDip, PGCert - University of Leicester
  • OSLER/OSCE examiner for HYMS students

Fellow of Higher Education Academy (FHEA)