Tim is Professor of Cardiovascular Biology in the HYMS Centre for Biomedicine at the University of Hull.
Tim obtained an Honours degree in Biochemistry at the University of Manchester and a PhD in Molecular Pharmacology at the University of Glasgow. He carried out postdoctoral training as an American Heart Association Research Fellow in the Cardiology Division at Duke University Medical Centre, North Carolina, USA.
He returned to the UK in 1997 as a Lecturer in Biochemistry at the University of Glasgow and developed an externally funded research programme focusing on cardiovascular cell signalling and disease.
From 2015 he was Professor of Pharmacology and Head of Pharmacology and Experimental Therapeutics at the School of Pharmacy and Medical Sciences at the University of Bradford, before being recruited to a Hull York Medical School Chair in Cardiovascular Biology at the University of Hull in 2018.
Tim's research interests are identifying the molecular mechanisms responsible for cardiovascular disease. Localised inflammation of branch points within large blood vessels is a pivotal event in the development of atherosclerotic plaque responsible for hear attack and stroke. Inflammation is driven by long-term exposure to chemical signals termed "cytokines" which trigger multiple pathways that ultimately lead to the defective vascular cell function responsible for cardiovascular disease. These processes are also responsible for the failure of bypass and stenting procedures used for acute treatment of patients who have suffered a heart attack.
Current projects:
Inhibition of pro-inflammatory JAK-STAT signalling by AMP-activated protein kinase to improve cardiovascular outcomes
Manipulation of suppressor of cytokine signalling 3 (SOCS3) stability and function to inhibit vascular inflammation and re-modelling
Exploiting novel protein-protein interactions as targets for new anti-inflammatory JAK-STAT signalling inhibitors
Design and delivery of sessions for Foundations in Pharmacology, Bench to Bedside 1 and Therapeutics modules in the MSc Pharmacology and Drug Development programme.
Design and delivery of Phase I and Phase II SSIP modules in pharmacology and cardiovascular disease.
Design and delivery of sessions for Cell Structure and Function, Human Physiology, Pathobiology, Cancer Biology and Challenges in Cardiovascular Science modules in the BSc Biomedical Science programme.
Personal supervision of BSc Biomedical Science and Forensic Science and MSc Biomedical Sciences students.
Supervision of postgraduate research degrees including MSc and PhD students.
A full publication list is available to view on Worktribe.
Selected publications
Williams JJL, Alotaiq N, Mullen W, Burchmore R, Liu L, Baillie GS, Schaper F, Pilch PF, Palmer TM. Interaction of suppressor of cytokine signalling 3 with cavin-1 links SOCS3 function and cavin-1 stability. Nat Commun. 2018 Jan 12;9(1):168. doi: 10.1038/s41467-017-02585-y.
Mancini SJ, White AD, Bijland S, Rutherford C, Graham D, Richter EA, Viollet B, Touyz RM, Palmer TM, Salt IP. Activation of AMP-activated protein kinase rapidly suppresses multiple pro-inflammatory pathways in adipocytes including IL-1 receptor-associated kinase-4 phosphorylation. Mol Cell Endocrinol. 2017 Jan 15;440:44-56. doi: 10.1016/j.mce.2016.11.010.
Rutherford C, Speirs C, Williams JJ, Ewart MA, Mancini SJ, Hawley SA, Delles C, Viollet B, Costa-Pereira AP, Baillie GS, Salt IP, Palmer TM. Phosphorylation of Janus kinase 1 (JAK1) by AMP-activated protein kinase (AMPK) links energy sensing to anti-inflammatory signaling. Sci Signal. 2016 Nov 8;9(453):ra109.
Rutherford C, Childs S, Ohotski J, McGlynn L, Riddick M, MacFarlane S, Tasker D, Pyne S, Pyne NJ, Edwards J, Palmer TM. Regulation of cell survival by sphingosine-1-phosphate receptor S1P1 via reciprocal ERK-dependent suppression of Bim and PI-3-kinase/protein kinase C-mediated upregulation of Mcl-1. Cell Death Dis. 2013 Nov 21;4:e927. doi: 10.1038/cddis.2013.455.
Cannavo A, Rengo G, Liccardo D, Pagano G, Zincarelli C, De Angelis MC, Puglia R, Di Pietro E, Rabinowitz JE, Barone MV, Cirillo P, Trimarco B, Palmer TM, Ferrara N, Koch WJ, Leosco D, Rapacciuolo A. β1-adrenergic receptor and sphingosine-1-phosphate receptor 1 (S1PR1) reciprocal downregulation influences cardiac hypertrophic response and progression to heart failure: protective role of S1PR1 cardiac gene therapy. Circulation. 2013 Oct 8;128(15):1612-22. doi: 10.1161/CIRCULATIONAHA.113.002659.
Long JS, Crighton D, O'Prey J, Mackay G, Zheng L, Palmer TM, Gottlieb E, Ryan KM. Extracellular adenosine sensing-a metabolic cell death priming mechanism downstream of p53. Mol Cell. 2013 May 9;50(3):394-406. doi: 10.1016/j.molcel.2013.03.016.
HYMS Centre for Biomedicine:
Prof. Roger Sturmey
Prof. David Allsup
Dr. Giordano Pula
Dr. Simon Calaminus
Dr. Leonid Nikitenko
HYMS Clinical Sciences Centre:
Prof. Dan Carradice
Prof. Thozhukat Sathyapalan
Honorary Prof. Mahmoud Loubani
Biomedical Engineering:
Dr. Amirpasha Moetazedian
University of Bradford:
Dr. Kirsten Riches-Suman
Dr. Ritchie Williamson
Dr. Sriharsha Kantamneni
Enquiries from prospective students welcome. 20 students successfully supervised to completion as principal supervisor.
Current students as principal supervisor are:
Laura Offler - Impact of glycaemic variation on endothelial cell regulation of vascular homeostasis.
Somia Abid - Evaluating novel SOCS3-mimetics to limit vein graft failure and in-stent re-stenosis.
Charlotte Cook - Platelet function studies in myeloproliferative neoplasm patients: can AMPK activators limit thrombosis?
2020-onwards:
Member and Chair of the Biochemical Society Research Area V: Signalling Panel
1996-1997; American Heart Association Basic Science Research Fellowship