respiratory

respiratory

Respiratory biology

Respiratory diseases are leading causes of death and disability in the world. About 65 million people suffer from chronic obstructive pulmonary disease (COPD) while asthma is the most common chronic disease in childhood affecting 14% of all children globally.

In collaboration with external partners and the Respiratory Research Group, our research focuses on the role of of thermo-TRP (Transient Receptor Potential channel) proteins and purinoceptors in cough and airway inflammation responsible for disease. Our aim is to understand the changes that occur in the airways in response to viruses, environmental stimuli and pharmaceuticals.

Projects

Understanding the mechanisms of post viral cough

Title: Understanding the mechanisms of post viral cough
Timeframe: 3 year project
Funder: University of Hull
Contact: Dr Laura R Sadofsky

The purpose of this research is to determine how the human rhinovirus causes post-viral cough.

Cough is frequently caused by respiratory viral infections such as the common cold. During, and post viral infection, our airways become more sensitive to cough stimuli such as smoke and cold air. We would like to determine the cause of this sensitivity and the mechanisms involved in order to develop better over the counter cough medicines.

Outputs

How does rhinovirus cause the common cold cough? BMJ Open Respir Res. 2016 Jan 13;3(1):e000118.

Models of the human airways

Title: Models of human airways
Timeframe: 3 year project
Funder: University of Hull
Contact: Dr Laura R Sadofsky

The purpose of this research is to develop in vitro models of the human airways using immortal cell lines or human cells and tissue to better understand inflammatory airways diseases and cough.

Models for the human airways, including animal models, are notoriously unreliable.  For example, asthma and the common cold are thought to be a uniquely human conditions.  We are therefore developing models of the human airways using human cells and tissue to investigate inflammatory conditions and the mechanism of cough to reduce animals used in experimentation and to better mimic what naturally occurs in humans.

Understanding the demulcent effect

Title: Understanding the demulcent effect
Timeframe: 3 year project
Contact: Dr Laura R Sadofsky

The purpose of this research is to determine the mode of action of demulcent activity.

Demulcents are the viscous, sweet component of cough medicines. How these substances relieve cough are not understood. We are therefore trying to understand, on a molecular level, how demulcents interact with the airways.

The effect of emerging environmental contaminants on the airways

Title: The effect of emerging environmental contaminants on the airways
Timeframe: 3 year project
Funder: University of Hull
Contact: Dr Laura R Sadofsky

The purpose of this research is to investigate the effect of emerging environmental contaminants on human airways using our in vitro human airway models.

The effect of emerging environmental contaminants, including 3D printer dust and microplastics, on respiratory disease development and exacerbations are not known. We therefore aim to investigate the effect of these emerging environmental contaminants on human airways using our newly developed models.