projects

projects

Projects

Here in the Wolfson Centre for Palliative Care Research, we strive to make a real and lasting improvements in the care which patients receive towards the end of their lives, and to the support provided to their families.

We believe that everybody has the right to the same, high-quality care, wherever and however they choose to be cared for. To this aim, our research projects follow the strategic objectives of the Wolfson Centre for Palliative Care:

Under-researched symptoms and problems

RAMBO

The aim of this project is to develop an agreed core outcome measurement set for research and clinical practice.

BreatheMOR-HF

Breathlessness is distressing for people with heart failure, and, as the condition worsens, may persist despite the best treatment. It’s already known breathlessness is safely improved by low-dose morphine in other conditions, such as cancer and chronic obstructive pulmonary disease. In this study, we tested if medium-term morphine therapy helps with breathlessness in heart failure patients.

Living with breathlessness: systematic review and qualitative synthesis

Living with breathlessness can be very difficult, affecting every area of life. However, there are things that can do to make life easier. This project addresses the large body of research on breathlessness to understand how patients' quality of life can be improved.

Bringing breathlessness into view

People living with breathlessness find their experience hard to describe to others. The aim of this project was to explore the idea of making an exhibition to show the public what it is like living with breathlessness.

Breathlessness RElief AT HomE (BREATHE)
We want to see if we could run a research study that tests if paramedics trained in breathlessness techniques is more effective for people in breathlessness crisis than usual care in easing breathlessness and help more people stay at home.

Select-d experience study

Cancer patients have a greater risk of venous thromboembolism than the general population. It is the commonest cause of death during chemotherapy. In this study, we explored patients and carers experience of cancer-associated thrombosis and its treatment.

HIDDEN

Treatment for deep vein thrombosis (DVT) is recommended for all patients with advanced cancer in hospitals, yet it is not routine practice for those in specialist palliative care units, such as hospices. The aim of this study was to determine how many cancer patients admitted to hospices have DVTs and whether these cause problems and will result in a better understanding of how we should treat people with advanced cancer.

Cancer patients’ experiences of living with venous thromboembolism : a systematic literature review

People with cancer have a high risk of developing blood clots in their veins. These clots are treated by blood thinner drugs (either injections or tablets). This project summarises published research about people's experience of living with cancer and blood clots and points out the shortage of information about this serious and potentially preventable issue. 

Reducing inequalities, improving access, and optimising delivery of care

NAT-ILD study

Here in the Wolfson Palliative Care Research Centre, we aim to help patients who have fibrosis of the lungs. We have developed a needs-assessment tool aimed to help doctors, nurses and respiratory/lung clinics to ask patients and carers about how their conditions are affecting their quality and life, to ensure their needs are dealt with effectively.

CAN-ASSESS

People with cancer need good access to palliative care, but we understand that not everyone gets the same access to these services. This can affect how well people cope with the cancer, and affect their quality of life. In this study, we are testing whether a large trial is feasible to see if the routine use of an assessment tool in cancer during routine practice makes a difference to patients.

Palliative care in the emergency department: qualitative systematic literature review and thematic synthesis

Palliative care is a much-needed purpose of the emergency department, in addition to its role in treating acute conditions. In this research, we aim to raise awareness of the experience of patients, famililes and carers so that they get they help they need.

Breathlessness and presentation to the emergency department: a survey and clinical record review

Breathlessness is a frequently occurring symptom of cardiorespiratory conditions and is a common cause of emergency department presentation. The aim of this study was to estimate the prevalence of acute-on-chronic breathlessness as a cause for presentation to the major emergencies area of the emergency department.

Does the International Control Board successfully balance its dual role as an enabler of access to medicine and a restrictor of illicit drug use: A discourse analysis of the annual reports of the INCB

The purpose of this project is to explore the discourse of the International Narcotics Control Board relating to enablement or restriction of narcotics, opiates, analgesia and opioids viewed through the lens of its annual reports 1968-2017

Access to opioid medication for cancer pain management in Asia: A systematic review of barriers and facilitators

Cancer patients in Asia have very limited access to necessary pain medicines for a number of complex reasons. This project investigates the published literature regarding the practical challenges for cancer patients in accessing pain medicines in Asian countries.

CANBENEFIT

Older people with cancer may not be fit enough to cope with some of the cancer treatments. There is some evidence to suggest that attention to exercise and diet may help people maintain their independence for longer and tolerate treatments better.

The aim of this study is to develop and model a complex nutrition and exercise intervention for older patients with lung cancer.

An exploratory systematic review and meta-analyses of airflow for the relief of chronic breathlessness in people with advanced disease

Many people live with continuing distress and difficulties arising from breathlessness despite treatment given to the underlying disease which causes it. This project addressed whether airflow provides relief of chronic breathlessness in people with advanced disease.

CHAFF (Calming Hand and Fan Feasibility trial)

This study looks at two options to help relieve breathlessness: a hand-held battery operated fan designed to give cool airflow to the face, and the Calming Hand, a simple breathing strategy that could help reduce anxiety that often occurs with breathlessness.

C-CHANGE project

NIHR-funded project (RP-PG-1210-12015) led by Prof Fliss Murtagh at King’s College London.

Proactive Anticipatory Care Evaluation (PACE) project

In a new and unique approach to health and care for older people, an innovative new facility – the Integrated Care Centre - opened in Hull in 2018. The first of its type in the UK, it’s set to transform care for older people. This study will evaluate this new service.

Improving wellbeing of those receiving palliative care, including measurement of outcomes
  • The Yorkshire Cancer Research-funded RESOLVE: Improving health status and symptom experience for people living with advanced cancer.
Develop better methods and testing novel approaches for palliative care research

Missing data study

Missing data has a huge impact on research, reducing the reliability of research findings. Here in the Wolfson Centre for Palliative Care, we are addressing why this happens and making recommendations how to to reduce research waste due to missing data.

Modified ITT

Clinical trials in palliative care are hard to conduct, and patient data is particularly precious - provided by patients who are unwell. It is important we find the best methods to analyse clinical trial participants under these circumstances.

The purpose of this project is to explore the effect of a modified intention-to-treat (ITT) analysis on the power and effect size of clinical trials in palliative care.